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Src signaling incancer invasion Marcello Guarino2010 год

Src signaling in cancer invasion
review

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Src is a non‐receptor cytoplasmic tyrosine kinase which becomes activated following the stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins, and is an indispensable player of multiple physiological homeostatic pathways. Once activated, Src is the starting point for several biochemical cascades that thereby propagate signals generated extracellularly along intracellular interconnected transduction pathways. Src transmits signals promoting cell survival and mitogenesis and, in addition, exerts a profound effect on the reorganization of the cytoskeleton and the adhesion systems that underpin cell migration and invasion. Because increased activity of Src is a frequent occurrence in many types of human cancer, and because there is evidence of a prominent role of Src in invasion and in other tumor progression‐related events such as epithelial–mesenchymal transition (EMT) and development of metastasis, inhibitors targeting Src are being viewed as promising drugs for cancer therapy. J. Cell. Physiol. 223: 14–26, 2010. © 2009 Wiley‐Liss, Inc.
Год издания: 2010
Авторы: Marcello Guarino
Издательство: Wiley
Источник: Journal of Cellular Physiology
Ключевые слова: Cell Adhesion Molecules Research, Wnt/β-catenin signaling in development and cancer, PI3K/AKT/mTOR signaling in cancer
Другие ссылки: Journal of Cellular Physiology (HTML)
PubMed (HTML)