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In vitroantibacterialactivity of someIranian medicinalplant extractsagainst Helicobacterpylori Mannan HajimahmoodiMohammadreza Shams‐ArdakaniParastoo Saniee2011 год

In vitro antibacterial activity of some Iranian medicinal plant extracts against Helicobacter pylori
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Helicobacter pylori infection causes lifelong chronic gastritis, which can lead to peptic ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer. The growing problem of antibiotic resistance by the organism demands the search for novel candidates from plant-based sources. In the present study, we evaluated the in vitro anti-H. pylori activity of some selected medicinal plants on clinical isolates of H. pylori. Gastric biopsy samples were obtained from patients presenting with gastroduodenal complications. Helicobacter pylori was isolated from the specimens following standard microbiology procedures. The disc-diffusion method was used to determine the susceptibility of three H. pylori isolates to methanol extracts of 23 Iranian plants. All tests were performed in triplicate. Among them, the extracts of Punica granatum and Juglans regia had remarkable anti-H. pylori activity with mean of inhibition zone diameter of 39 and 16 mm at 100 µg disc−1, respectively. In view of the results obtained with P. granatum (pomegranate), the peel extracts of nine cultivars of pomegranate (Shirin-e-Pust Sefid, Agha Mohammad Ali-e-Shirin, Sefid-e-Shomal, Sefid-e-Torsh, Shirin-e-Malase, Tabestani-e-Torsh, Shirin-e-Saveh Malase, Alak-e-Shirin, Pust Siyah) were further assayed against the clinical isolates of H. pylori. The results revealed that all Iranian pomegranate cultivars, except for Alak-e-Shirin, showed significant in vitro anti-H. pylori activity against the clinical isolates of H. pylori (mean of inhibition zone diameter ranging from 16 to 40 mm at 50 µg disc−1).
Год издания: 2011
Авторы: Mannan Hajimahmoodi, Mohammadreza Shams‐Ardakani, Parastoo Saniee, Farideh Siavoshi, Mitra Mehrabani, Hossein Hosseinzadeh, Parham Foroumadi, Maliheh Safavi, Mahnaz Khanavi, Tahmineh Akbarzadeh, Abbas Shafiee, Alireza Foroumadi
Издательство: Taylor & Francis
Источник: Natural Product Research
Ключевые слова: Pomegranate: compositions and health benefits, Garlic and Onion Studies, Helicobacter pylori-related gastroenterology studies
Другие ссылки: Natural Product Research (HTML)
PubMed (HTML)