1. Главная
  2. Ресурсы
  3. Библиотечный поиск
MicroRNAs asMediators of theAgeing Process Lorna W. Harries2014 год

MicroRNAs as Mediators of the Ageing Process
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Human ageing is a complex and integrated gradual deterioration of cellular processes. There are nine major hallmarks of ageing, that include changes in DNA repair and DNA damage response, telomere shortening, changes in control over the expression and regulation of genes brought about by epigenetic and mRNA processing changes, loss of protein homeostasis, altered nutrient signaling, mitochondrial dysfunction, stem cell exhaustion, premature cellular senescence and altered intracellular communication. Like practically all other cellular processes, genes associated in features of ageing are regulated by miRNAs. In this review, I will outline each of the features of ageing, together with examples of specific miRNAs that have been demonstrated to be involved in each one. This will demonstrate the interconnected nature of the regulation of transcripts involved in human ageing, and the role of miRNAs in this process. Definition of the factors involved in degeneration of organismal, tissue and cellular homeostasis may provide biomarkers for healthy ageing and increase understanding of the processes that underpin the ageing process itself.
Год издания: 2014
Авторы: Lorna W. Harries
Издательство: Multidisciplinary Digital Publishing Institute
Источник: Genes
Ключевые слова: MicroRNA in disease regulation, Genetics, Aging, and Longevity in Model Organisms, Telomeres, Telomerase, and Senescence
Другие ссылки: Genes (PDF)
Genes (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Open Research Exeter (University of Exeter) (PDF)
Open Research Exeter (University of Exeter) (HTML)
PubMed Central (HTML)
PubMed (HTML)