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Dietary Glycemic Loadand Index and Risk ofCoronary HeartDisease in a LargeItalian Cohort Sabina SieriVittorio KroghFranco Berrino2010 год

Dietary Glycemic Load and Index and Risk of Coronary Heart Disease in a Large Italian Cohort
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация:

Background

Dietary glycemic load (GL) and glycemic index (GI) in relation to cardiovascular disease have been investigated in a few prospective studies with inconsistent results, particularly in men. The present EPICOR study investigated the association of GI and GL with coronary heart disease (CHD) in a large and heterogeneous cohort of Italian men and women originally recruited to the European Prospective Investigation into Cancer and Nutrition study.

Methods

We studied 47 749 volunteers (15 171 men and 32 578 women) who completed a dietary questionnaire. Multivariate Cox proportional hazards modeling estimated adjusted relative risks (RRs) of CHD and 95% confidence intervals (CIs).

Results

During a median of 7.9 years of follow-up, 463 CHD cases (158 women and 305 men) were identified. Women in the highest carbohydrate intake quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.00; 95% CI, 1.16-3.43), with no association found in men (P = .04 for interaction). Increasing carbohydrate intake from high-GI foods was also significantly associated with greater risk of CHD in women (RR, 1.68; 95% CI, 1.02-2.75), whereas increasing the intake of low-GI carbohydrates was not. Women in the highest GL quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.24; 95% CI, 1.26-3.98), with no significant association in men (P = .03 for interaction).

Conclusion

In this Italian cohort, high dietary GL and carbohydrate intake from high-GI foods increase the overall risk of CHD in women but not men.
Год издания: 2010
Авторы: Sabina Sieri, Vittorio Krogh, Franco Berrino, Alberto Gonçalves Evangelista, Claudia Agnoli, Furio Brighenti, Nicoletta Pellegrini, Domenico Palli, Giovanna Masala, Carlotta Sacerdote, Fabrizio Veglia, ­Rosario ­Tumino, Graziella Frasca, Sara Grioni, Valeria Pala, Amalia Mattiello, Paolo Chiodini, Salvatore Panico
Издательство: American Medical Association
Источник: Archives of Internal Medicine
Ключевые слова: Nutritional Studies and Diet, Food composition and properties, Diet, Metabolism, and Disease
Другие ссылки: Archives of Internal Medicine (HTML)
PubMed (HTML)