Anophthalmos, Microphthalmos, and Typical Coloboma in the United Kingdom: A Prospective Study of Incidence and Riskстатья из журнала
Аннотация: Anophthalmos, microphthalmos, and typical coloboma (AMC) form an interrelated spectrum of congenital eye anomalies that can cause significant visual loss and cosmetic disfigurement in children. This prospective study of children born in the United Kingdom was undertaken to determine the incidence of AMC diagnosed by ophthalmologists and to explore sociodemographic risks.Recruitment was achieved though an established active surveillance system of U.K. ophthalmologists supported by a new research network of interested specialists, the Surveillance of Eye Anomalies (SEA-UK) Special Interest Group. It started October 1, 2006, and continued over 18 months.One hundred thirty-five children were newly diagnosed with AMC. Typical colobomatous defects were the commonest phenotype, and anophthalmos was rare (n = 7). Both eyes were affected in 55.5% of the children. The cumulative incidence of AMC by age 16 years was 11.9 per 100,000 (95% CI, 10.9-15.4). Of the children examined, 41.5% had not seen an ophthalmologist by 3 months of age. The incidence in Scotland was nearly double that in England and Wales. The children of Pakistani ethnicity had a 3.7 (95% CI, 1.9-7.5) times higher risk of AMC than did white children. There was some evidence to suggest a higher incidence in the more socioeconomically deprived. The sibling risk ratio was 210 (95% CI, 25-722).This is the first prospective study of AMC, and it establishes the frequency across the United Kingdom. Comparisons with data quoted in the literature are difficult because study methodologies differ, but the frequency appears to be lower than that quoted for other developed countries. There are geographic and ethnic variations in incidence that warrant further investigation.
Год издания: 2010
Авторы: Shaheen P. Shah, Amy E. Taylor, Jane C. Sowden, Nicola Ragge, Isabelle Russell‐Eggitt, Jugnoo S. Rahi, Clare Gilbert
Издательство: Cadmus Press
Источник: Investigative Ophthalmology & Visual Science
Ключевые слова: Ocular Disorders and Treatments, Congenital Ear and Nasal Anomalies, Reconstructive Facial Surgery Techniques
Другие ссылки: Investigative Ophthalmology & Visual Science (HTML)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (HTML)
PubMed (HTML)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (HTML)
PubMed (HTML)
Открытый доступ: green
Том: 52
Выпуск: 1
Страницы: 558–558