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Ultrastructurallocalization of CART(cocaine- andamphetamine-regulatedtranscript) peptidesin the nucleusaccumbens of monkeys Yoland SmithErsin O. KoyluPastor R. Couceyro1997 год

Ultrastructural localization of CART (cocaine- and amphetamine-regulated transcript) peptides in the nucleus accumbens of monkeys
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Аннотация: CART (cocaine- and amphetamine-regulated transcript) peptides are proposed to play a role in the action of psychostimulants as neurotransmitters/neuromodulators. In the present study, we demonstrate that the shell of the nucleus accumbens, a brain structure involved in drug reinforcement, is densely innervated by a dense plexus of CART peptide-immunoreactive varicose fibers in register with immunoreactive perikarya in monkeys. At the electron microscopic level, varicosities appeared as immunoreactive axon terminals packed with round electron-lucent vesicles and a variable number of darkly stained dense-core vesicles that formed symmetric synapses with dendrites. These findings suggest that CART peptides may be a cotransmitter with gamma aminobutyric acid (GABA) in intrinsic axon collaterals of striatal projection neurons or interneurons in the primate nucleus accumbens. Synapse 27:90–94, 1997. © 1997 Wiley-Liss, Inc.
Год издания: 1997
Авторы: Yoland Smith, Ersin O. Koylu, Pastor R. Couceyro, Michael J. Kuhar
Издательство: Wiley
Источник: Synapse
Ключевые слова: Adipose Tissue and Metabolism, Regulation of Appetite and Obesity, Pancreatic function and diabetes
Другие ссылки: Synapse (HTML)
PubMed (HTML)