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Melanocytic Nevi asBiomarkers of BreastCancer Risk Barbara J. FuhrmanVíctor M. Cárdenas2014 год

Melanocytic Nevi as Biomarkers of Breast Cancer Risk
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Аннотация: report on their number of moles using qualitative categories as follows: ‘‘none,’’ ‘‘a few,’’ ‘‘many,’’ or ‘‘very many.’’ The cohort was followed through 2008; a total of 5,956 incident breast cancer cases were ascertained over nearly 1.4 million personyears. In age-adjusted models, women reporting the most nevi were observed to have 13% higher breast cancer risk than their counterparts without nevi (p for trend=0.04). This association was attenuated and the trend no longer significant when investigators adjusted for benign breast disease or family history of breast cancer. A non-statistically significant increase in breast cancer risk of 8% was observed after adjusting for established breast cancer risk factors and measures of ultraviolet radiation exposure. While their findings are broadly consistent, subgroup findings in the two studies were different. Kvaskoff and colleagues found no significant association in postmenopausal women, but observed that, among premenopausal women, those who had reported ‘‘very many’’ nevi were 34% more likely to be diagnosed with breast cancer compared to counterparts who reported ‘‘none’’ even after adjustment for all potential confounders (p for trend=0.03, p for heterogeneity=0.04). In contrast, Han and colleagues found no significant modification of the risk association by menopausal status. The association between nevi and breast cancer risk is unlikely to be causal. Both melanocytic nevi and melanoma are derived from melanin-producing cells in dermal or epidermal tissues [5]; in contrast, most breast cancers are thought to arise from epithelial cells of ductal or lobular origin [6]. Given their
Год издания: 2014
Авторы: Barbara J. Fuhrman, Víctor M. Cárdenas
Издательство: Public Library of Science
Источник: PLoS Medicine
Ключевые слова: Cutaneous Melanoma Detection and Management, Cancer and Skin Lesions, Nonmelanoma Skin Cancer Studies
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