Аннотация:n this issue of the Journal, Baseggio et al. 1 report on a series of 24 patients with CD5-positive, t(11;14)-negative splenic marginal zone lymphoma (SMZL) diagnosed by means of cytology and flow cytometry of peripheral blood.All the patients were splenectomized at diagnosis or during follow-up and, consequently, spleen specimens were available for histological examination in all cases.The biological features of the CD5-positive SMZL cases did not appear to be different from those of a comparative series of 42 CD5-negative SMZL cases with the exception of a tendency to a more mutated immunoglobulin variable heavy chain genes (IGHV) sta-tus.Clinically, CD5-positive SMZL were characterized only by more marked lymphocytosis at diagnosis and more frequent diffuse bone marrow infiltration.No significant differences were found in outcome.
