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Prevalence andgenotype distributionof humanpapillomavirusinfection of thecervix in Spain: TheCLEOPATRE study Xavier CastellsaguéThomas IftnerEsther Roura2012 год

Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: The CLEOPATRE study
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. The aim of this study was to estimate the prevalence of cervical HPV infection and HPV type‐specific distribution among women attending cervical cancer screening in Spain during 2007 and 2008. Women aged 18–65 years were recruited according to an age‐stratified sampling method. Liquid‐based cervical samples were collected and analyzed for cytology, HPV detection, and genotyping. HPV genotyping was determined using the INNO‐LiPA HPV Genotyping Extra Reverse Hybridization Line Probe Assay. Prevalence estimates were age‐standardized using 2001 Spanish census data. The present study included 3,261 women. Age‐standardized HC2‐based HPV prevalence was 14.3% (95% CI, 13.1–15.5) among women aged 18–65 years, and 28.8% (26.6–31.1) among women aged 18–25 years. High‐risk HPV types were detected in 12.2% (95% CI, 11.1–13.4) of HPV‐tested women, representing 84.0% of HPV‐positive samples. Multiple infections were present in 4.1% (95% CI, 3.4–4.8) of HPV‐tested women (25.0% of HPV‐positive samples). The most common high‐risk HPV‐types among HPV‐tested women were 16 (2.9%), 52 (1.8%), 51 (1.6%), 31 (1.3%), and 66 (1.2%). HPV‐type 16 was present in 16.9% of HPV‐positive samples. One or more of the HPV vaccine types 6/11/16/18 were detected in 3.8% of HPV‐tested women (22.1% of HPV‐positive samples). Though not a true population‐based survey, this study provides valuable baseline data for future assessment of the impact of current HPV vaccination programs in Spain. The high prevalence of HPV infection among young women may reflect recent changes in sexual behavior. J. Med. Virol. 84:947–956, 2012. © 2012 Wiley Periodicals, Inc.
Год издания: 2012
Авторы: Xavier Castellsagué, Thomas Iftner, Esther Roura, José Antonio Vidart, Susanne K. Kjær, F. Xavier Bosch, Núbia Muñóz, Santiago Palacios, María San Martín Rodríguez, Laurence Serradell, Laurence Torcel‐Pagnon, Javier Cortés
Издательство: Wiley
Источник: Journal of Medical Virology
Ключевые слова: Cervical Cancer and HPV Research, Hepatitis B Virus Studies, Genital Health and Disease
Другие ссылки: Journal of Medical Virology (HTML)
PubMed (HTML)