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Appraising organisedscreening programmesfor testing forgeneticsusceptibility tocancer Vivek Goel2001 год

Appraising organised screening programmes for testing for genetic susceptibility to cancer
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Аннотация: Public health officials rely on criteria developed by Wilson and Jungner for assessing whether or not to implement population screening programmes. These criteria were developed over 30 years ago, when screening primarily focused on detecting early stages or precursors of chronic disease. With the introduction of testing for genetic susceptibility, particularly for cancer, it is important to assess whether these criteria can continue to be applied in the decision making process. We report on a workshop that assessed criteria for population screening in the context of testing for genetic susceptibility to cancer. Many criteria for the evaluation of screening programmes have been proposed, 1 2 and most are similar to those proposed by Wilson and Jungner in a 1968 World Health Organization report.3 The criteria are based on a simple linear model of disease progression (figure) in which screening tests primarily detect a preclinical asymptomatic phase. #### Summary points Screening has expanded from early detection of disease or its precursors to include testing for susceptibility, such as genetic testing for cancer The Wilson and Jungner framework for evaluating screening tests, produced for the World Health Organization in 1968, is commonly used for population screening The relevance of this framework for testing for genetic susceptibility to cancer has not previously been assessed A modified Wilson and Jungner framework can continue to provide a robust approach to evaluating testing for genetic susceptibility The continuum of screening has expanded to include a range of other states. The figure illustrates another model for screening—screening for risk factors or susceptibility, the detection of risk factors for disease4 (such as blood pressure or cholesterol concentration), or the identification, through the detection of genetic markers, of individuals who have increased susceptibility to disease.5 Separate consideration of these forms of screening is important as the type of interventions …
Год издания: 2001
Авторы: Vivek Goel
Издательство: BMJ
Источник: BMJ
Ключевые слова: BRCA gene mutations in cancer, Genetic Associations and Epidemiology, Genomics and Rare Diseases
Другие ссылки: BMJ (HTML)
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Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)