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P3‐053: APOE E4affects spatialworking memory andattention in patientswith amnestic mildcognitive impairment Jan LaczóKamil VlčekMartin Vyhnálek2009 год

P3‐053: APOE E4 affects spatial working memory and attention in patients with amnestic mild cognitive impairment
статья из журнала

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Аннотация: Our goal was to investigate effect of APOE ϵ4 (ϵ4) on spatial working memory (SWM) and attention in amnestic mild cognitive impairment (aMCI) patients and to assess characteristics of the impairment in ϵ4 negative (ϵ4-) and ϵ4 positive (ϵ4+) aMCI subgroups. A total of 58 aMCI patients were stratified according to ϵ4 positivity into aMCI-ϵ4- (n=31) and aMCI-ϵ4+ (n=27) subgroups and compared to control (n=27) and AD (n=15) groups. The aMCI subgroups did not differ in basic characteristics or any neuropsychological tests. We used the Concurrent approach and avoid task (CAAT) designed as an analogue of the Active place avoidance task used in rodents. The subjects watched a computer screen with a regular dodecagon representing an arena. There were six 60 second phases. The subjects' task in the first two phases was to remember and subsequently locate a hidden target (Approach task), which appeared for two seconds at the beginning of each trial in the arena, indicating when a quasi-random moving cursor reached the target. In the subsequent two phases the subjects avoided two visible objects (Avoidance task) preventing the cursor to collide with the objects by pressing the spacebar. In the last two phases the subjects should do both things together - locate the hidden target and avoid the visible objects (Approach & Avoidance task). The aMCI-ϵ4+ group exhibited poorer performance in locating the target than the aMCI-ϵ4- group. Using the control group as the reference, the aMCI-ϵ4+ and AD groups were similarly impaired in all tasks. The aMCI-ϵ4- group was slightly impaired in locating the target and in concurrent avoiding objects with locating the target. We found a more profound SWM deficit in aMCI-ϵ4+ relative to aMCI-ϵ4- patients. The aMCI-ϵ4+ patients also showed the same SWM and attentional impairment as AD patients. The CAAT can identify individuals at higher risk for AD among heterogeneous MCI population.
Год издания: 2009
Авторы: Jan Laczó, Kamil Vlček, Martin Vyhnálek, Václav Maťoška, Irena Buksakowska, Hana Magerová, Alexandra Varjassyová, Iva Holmerová, Hana Vaňková, Daniel Hořínek, Martin Tolar, Ross Andel, Martin Bojar, Jakub Hort
Издательство: Wiley
Источник: Alzheimer s & Dementia
Ключевые слова: Health, Environment, Cognitive Aging