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Elevation ofTumor-associatedCarbohydrate Antigensin Patients withDiffusePanbronchiolitis Hiroshi MukaeMasaki HirotaShigeru Kohno1993 год

Elevation of Tumor-associated Carbohydrate Antigens in Patients with Diffuse Panbronchiolitis
статья из журнала

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Аннотация: We investigated the serum levels of the tumor-associated carbohydrate antigens sialyl SSEA-1 (SLX) and sialyl Lewisa (CA19-9) in patients with diffuse panbronchiolitis (DPB) and other nonmalignant lung diseases. Both antigens were high in the serum and bronchoalveolar lavage fluid (BALF) of patients with DPB, bronchiectasis (BE), idiopathic pulmonary fibrosis (IPF), and interstitial pneumonia associated with collagen vascular disease (CVD). Markedly high levels of the antigens were demonstrated in the serum and BALF from patients with DPB. An immunohistochemical study of open-lung biopsy specimens from patients with DPB indicated that these antigens were selectively expressed on the bronchiolar epithelial cells and mucinous exudates in airspaces. Low-dose, long-term erythromycin (EM) treatment was recently reported to be effective for DPB, and we investigated its influence on serum and BALF antigen levels in DPB patients. Antigen levels in both serum and BALF decreased after EM treatment, with improvement of symptoms and laboratory data, and there was a significant correlation between the reduction in the SLX level in serum and neutrophil percentage in BALF pre- and post-EM treatment. Our result suggests that secreted carbohydrate antigens from the bronchiolar epithelium in DPB may appear in the serum as a result of airway damage in the lower respiratory tract, and serum levels of the antigens may be decreased by a reduction in neutrophils in BALF after EM treatment.
Год издания: 1993
Авторы: Hiroshi Mukae, Masaki Hirota, Shigeru Kohno, Kiyotaka Komori, Kiyoyasu Fukushima, Kazuhito Hiratani, Jun‐ichi Kadota, Kohei Hara
Издательство: American Thoracic Society
Источник: American Review of Respiratory Disease
Ключевые слова: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis, Medical Imaging and Pathology Studies, Neonatal Respiratory Health Research
Другие ссылки: American Review of Respiratory Disease (HTML)
PubMed (HTML)