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Expression of Crerecombinase in thedeveloping mouse limbbud driven by a Prxlenhancer Malcolm LoganJames F. MartinAndrás Nagy2002 год

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer
статья из журнала

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Аннотация: Abstract Summary: We have used a Prx1 limb enhancer to drive expression of Cre Recombinase in transgenic mice. This regulatory element leads to Cre expression throughout the early limb bud mesenchyme and in a subset of craniofacial mesenchyme. Crossing a murine line carrying this transgene to a reporter mouse harboring a floxed Cre‐reporter cassette revealed that recombinase activity is first observed in the earliest limb bud at 9.5 dpc. By early to mid bud stages at 10.5 dpc recombination is essentially complete in all mesenchymal cells in the limb. Expression of the Cre recombinase was never detected in the limb bud ectoderm. The use of Prx1 – Cre mice should facilitate analysis of gene function in the developing limb. genesis 33:77–80, 2002. © 2002 Wiley‐Liss, Inc.
Год издания: 2002
Авторы: Malcolm Logan, James F. Martin, András Nagy, Corrinne G. Lobe, Eric N. Olson, Clifford J. Tabin
Издательство: Wiley
Источник: genesis
Ключевые слова: Developmental Biology and Gene Regulation, Genomics and Chromatin Dynamics, Animal Genetics and Reproduction
Другие ссылки: genesis (HTML)
PubMed (HTML)