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Italian MulticenterStudy on Low‐DensityLipoprotein ApheresisWorking Group 2009Survey Claudia StefanuttiClaudia MorozziS. Di Giacomo2013 год

Italian Multicenter Study on Low‐Density Lipoprotein Apheresis Working Group 2009 Survey
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Аннотация: Abstract We present results of the second survey of the Italian Multicenter Study on Low‐Density Lipoprotein Apheresis (IMSLDLa‐WG/2). The study involved 18 centers in 2009, treating 66 males and 35 females, mean age 47 ± 18 years. Mean age for initiation of drug treatment before low‐density lipoprotein apheresis (LDLa) was 31 ± 18 years, mean age to the first LDLa was 37 ± 20 years and average duration of treatment was 9 ± 6 years. The techniques used included direct adsorption of lipids, dextran sulfate cellulose adsorption, heparin‐mediated low‐density lipoprotein (LDL) precipitation, cascade filtration, and plasma exchange. The mean treated plasma/blood volumes/session were 3127 ± 518 mL and 8666 ± 1384 mL, respectively. The average plasma volume substituted was 3500 ± 300 mL. Lipid therapy before LDLa included ezetimibe, statins, ω‐3 fatty acids and fenofibrate. Baseline mean LDL cholesterol (LDLC) levels were 386 ± 223 mg/dL. The mean before/after apheresis LDLC level decreased by 67% from 250 ± 108 mg/dL ( P = 0.05 vs. baseline) to 83 ± 37 mg/dL ( P = 0.001 vs. before). Baseline mean Lipoprotein(a) [Lp(a)] level was 179 ± 136 mg/dL. Mean before/after apheresis Lp(a) level decreased by 71% from 133 ± 120 mg/dL ( P = 0.05 vs. baseline) to 39 ± 44 mg/dL ( P = 0.001 vs. before). Major and minor side effects occurred in 27 and 62 patients, respectively. Among patients with coronary artery disease (CAD), 62.3% had coronary angiography and 50.4% coronary revascularization before LDLa. Single vessel, double vessel and triple vessel CAD occurred in 19 (30.1%), 15 (23.8%) and 29 (46%) patients, respectively. Both CAD and extra‐CAD occurred in 41.5%, 39% had hypertension, 9.9% were smokers, 9.9% consumed alcohol and 42% were physically active. Ischemic cardiovascular events were not observed in any patient over 9 ± 6 years of treatment. Two centers have also treated 34 patients (females: 17/males 17; no. sessions: 36; average plasma volume treated: 3000 mL) for sudden hearing loss (SHL). Relief of symptoms was obtained, independently of the system used (HELP; cascade‐filtration).
Год издания: 2013
Авторы: Claudia Stefanutti, Claudia Morozzi, S. Di Giacomo
Издательство: Wiley
Источник: Therapeutic Apheresis and Dialysis
Ключевые слова: Lipoproteins and Cardiovascular Health, Blood Coagulation and Thrombosis Mechanisms, Systemic Lupus Erythematosus Research
Другие ссылки: Therapeutic Apheresis and Dialysis (HTML)
PubMed (HTML)