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Target risk factorsfor dementiaprevention: asystematic review andDelphi consensusstudy on the evidencefrom observationalstudies Kay DeckersMartin P.J. van BoxtelOlga J.G. Schiepers2014 год

Target risk factors for dementia prevention: a systematic review and Delphi consensus study on the evidence from observational studies

Страница публикацииПубликация в OpenAlex
Аннотация: Objective Dementia has a multifactorial etiology, but the importance of individual health and lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper is to identify the major modifiable risk factors for dementia as a first step in developing an effective preventive strategy and promoting healthy late life cognitive functioning. Methods A mixed-method approach combined findings from a systematic literature review and a Delphi consensus study. The literature search was conducted in PubMed and updated an earlier review by the United States National Institutes of Health from 2010. We reviewed the available evidence from observational epidemiological studies. The online Delphi study asked eight international experts to rank and weigh each risk factor for its importance for dementia prevention. Results Out of 3127 abstracts, 291 were included in the review. There was good agreement between modifiable risk factors identified in the literature review and risk factors named spontaneously by experts. After triangulation of both methods and re-weighting by experts, strongest support was found for depression, (midlife) hypertension, physical inactivity, diabetes, (midlife) obesity, hyperlipidemia, and smoking, while more research is needed for coronary heart disease, renal dysfunction, diet, and cognitive activity. Conclusions Findings provide good support for several somatic and lifestyle factors and will be used to inform the design of a new multicenter trial into dementia prevention. Copyright © 2014 John Wiley & Sons, Ltd.
Год издания: 2014
Авторы: Kay Deckers, Martin P.J. van Boxtel, Olga J.G. Schiepers, Marjolein E. de Vugt, Juan Luis Sánchez, Kaarin J. Anstey, Carol Brayne, Jean‐François Dartigues, Knut Engedal, Miia Kivipelto, Karen Ritchie, John M. Starr, Kristine Yaffe, Kate Irving, Frans R.J. Verhey, Sebastian Köhler
Издательство: Wiley
Источник: International Journal of Geriatric Psychiatry
Ключевые слова: Delphi Technique in Research, Dementia and Cognitive Impairment Research, Maternal Mental Health During Pregnancy and Postpartum
Другие ссылки: International Journal of Geriatric Psychiatry (HTML)
PubMed (HTML)