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Real‐time monitoringof exhaled drugs bymass spectrometry Christian BerchtoldMarija BosilkovskaYoussef Daali2013 год

Real‐time monitoring of exhaled drugs by mass spectrometry
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Abstract Future individualized patient treatment will need tools to monitor the dose and effects of administrated drugs. Mass spectrometry may become the method of choice to monitor drugs in real time by analyzing exhaled breath. This review describes the monitoring of exhaled drugs in real time by mass spectrometry. The biological background as well as the relevant physical properties of exhaled drugs are delineated. The feasibility of detecting and monitoring exhaled drugs is discussed in several examples. The mass spectrometric tools that are currently available to analyze breath in real time are reviewed. The technical needs and state of the art for on‐site measurements by mass spectrometry are also discussed in detail. Off‐line methods, which give support and are an important source of information for real‐time measurements, are also discussed. Finally, some examples of drugs that have already been successfully detected in exhaled breath, including propofol, fentanyl, methadone, nicotine, and valproic acid are presented. Real‐time monitoring of exhaled drugs by mass spectrometry is a relatively new field, which is still in the early stages of development. New technologies promise substantial benefit for future patient monitoring and treatment. © 2013 Wiley Periodicals, Inc. Mass Spec Rev 33: 394–413, 2014
Год издания: 2013
Авторы: Christian Berchtold, Marija Bosilkovska, Youssef Daali, Bernhard Walder, Renato Zenobi
Издательство: Wiley
Источник: Mass Spectrometry Reviews
Ключевые слова: Advanced Chemical Sensor Technologies, Mass Spectrometry Techniques and Applications, Analytical Chemistry and Chromatography
Другие ссылки: Mass Spectrometry Reviews (PDF)
Mass Spectrometry Reviews (HTML)
PubMed (HTML)