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Reply Ho Cheol HongKyung Mook Choi2015 год

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Аннотация: Potential conflict of interest: Nothing to report. We appreciate the interest of Dr. Pang and colleagues in our article about a relationship between sarcopenia and nonalcoholic fatty liver disease (NAFLD).1 They suggest that the association between sarcopenia and NAFLD may partially be related to low vitamin D status. The increase of an indoor lifestyle and aging society has brought deficiency of vitamin D in the general population. Traditionally, vitamin D has been regarded as a vital factor for bone health and calcium metabolism. Recently, deficiency of vitamin D has been known to be associated with chronic metabolic disorders, including type 2 diabetes, obesity, metabolic syndrome, and cardiovascular disease, beyond calcium and bone metabolism. Furthermore, low vitamin D levels are associated with decreased muscle mass and strength. Visser et al. reported that lower 25‐hydroxyvitamin D (25[OH]D) levels increase risk of sarcopenia in older men and women.2 In addition, 25(OH)D levels were positively associated with skeletal muscle mass in our previous study.3 Accumulating evidences support that low 25(OH)D status may be associated with both sarcopenia and low physical activity. As shown by Dr. Pang and colleagues, the relationship between vitamin D levels and NAFLD has been increasingly recognized. Recently, Barchetta et al. reported that low 25(OH)D levels are associated with the presence of NAFLD, independent of metabolic syndrome, diabetes, and insulin‐resistant profiles.4 In conclusion, we agree with Dr. Pang's opinion that vitamin D deficiency, sarcopenia, and NAFLD may be linked together. Further studies might be needed to explore the pathogenic and therapeutic implications of vitamin D in patients with NAFLD and sarcopenia.
Год издания: 2015
Авторы: Ho Cheol Hong, Kyung Mook Choi
Издательство: Lippincott Williams & Wilkins
Источник: Hepatology
Ключевые слова: Vitamin D Research Studies, Nutrition and Health in Aging, Diet and metabolism studies
Другие ссылки: Hepatology (PDF)
Hepatology (HTML)
PubMed (HTML)