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Manganese homeostasisin the nervous system Pan ChenSudipta ChakrabortySomshuvra Mukhopadhyay2015 год

Manganese homeostasis in the nervous system
review

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Аннотация: Abstract Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn‐induced neurotoxicity. image Though and essential metal, overexposure to manganese may result in neurodegenerative disease analogous to Parkinson's disease. Manganese homeostasis is tightly regulated by transporters, including transmembrane importers (divalent metal transporter 1, transferrin and its receptor, zinc transporters ZIP8 and Zip14, dopamine transporter, calcium channels, choline transporters and citrate transporters) and exporters (ferroportin and SLC30A10), as well as the intracellular trafficking proteins (SPCA1 and ATP12A2). A manganese‐specific sensor, GPP130, has been identified, which affords means for monitoring intracellular levels of this metal.
Год издания: 2015
Авторы: Pan Chen, Sudipta Chakraborty, Somshuvra Mukhopadhyay, Eun‐Sook Lee, Mônica Maria Bastos Paoliello, Aaron B. Bowman, Michael Aschner
Издательство: Wiley
Источник: Journal of Neurochemistry
Ключевые слова: Trace Elements in Health, Heavy Metal Exposure and Toxicity, Iron Metabolism and Disorders
Другие ссылки: Journal of Neurochemistry (HTML)
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Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
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