1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Genetic ablation ofNMDA receptor subunitNR3B in mouse revealsmotoneuronal andnonmotoneuronalphenotypes Stephan NiemannHiroaki KankiYasuyuki Fukui2007 год

Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes
статья из журнала

Страница публикацииПубликация в OpenAlex
Аннотация: Abstract NR3B is a modulatory subunit of the NMDA receptor, abundantly expressed in both cranial and spinal somatic motoneurons and at lower levels in other regions of the brain as well. Recently, we found the human NR3B gene ( GRIN3B ) to be highly genetically heterogeneous, and that ∼ 10% of the normal European‐American population lacks NR3B due to homozygous occurrence of a null allele in the gene. Therefore, it is especially important to understand the phenotypic consequences of the genetic loss of NR3B in both humans and animal models. We here provide results of behavioral analysis of mice genetically lacking NR3B, which is an ideal animal model due to homogeneity in genetic and environmental background. The NR3B –/– mice are viable and fertile. Consistent with the expression of NR3B in somatic motoneurons, the NR3B –/– mice showed a moderate but significant impairment in motor learning or coordination, and decreased activity in their home cages. Remarkably, the NR3B –/– mice showed a highly increased social interaction with their familiar cage mates in their home cage but moderately increased anxiety‐like behaviour and decreased social interaction in a novel environment, consistent with the inhibitory role of NR3B on the functions of NMDA receptors. This work is the first reporting of the functional significance of NR3B in vivo and may give insight into the contribution of genetic variability of NR3B in the phenotypic heterogeneity among human population.
Год издания: 2007
Авторы: Stephan Niemann, Hiroaki Kanki, Yasuyuki Fukui, Keizo Takao, Masahiro Fukaya, Meri Hynynen, Michael Churchill, Jeremy M. Shefner, Roderick T. Bronson, Robert H. Brown, Masahiko Watanabe, Tsuyoshi Miyakawa, Shigeyoshi Itohara, Yasunori Hayashi
Издательство: Wiley
Источник: European Journal of Neuroscience
Ключевые слова: Neuroscience and Neuropharmacology Research, Neuroendocrine regulation and behavior, Neurogenesis and neuroplasticity mechanisms
Другие ссылки: European Journal of Neuroscience (HTML)
PubMed (HTML)