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The management ofiron deficiency ininflammatory boweldisease - an onlinetool developed by theRAND/UCLAappropriatenessmethod Walter ReinischYehuda ChowersSilvio Danese2013 год

The management of iron deficiency in inflammatory bowel disease - an online tool developed by the RAND/UCLA appropriateness method
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Аннотация: Background Iron deficiency is a common and undertreated problem in inflammatory bowel disease (IBD). Aim To develop an online tool to support treatment choice at the patient-specific level. Methods Using the RAND/UCLA Appropriateness Method (RUAM), a European expert panel assessed the appropriateness of treatment regimens for a variety of clinical scenarios in patients with non-anaemic iron deficiency (NAID) and iron deficiency anaemia (IDA). Treatment options included adjustment of IBD medication only, oral iron supplementation, high-/low-dose intravenous (IV) regimens, IV iron plus erythropoietin-stimulating agent (ESA), and blood transfusion. The panel process consisted of two individual rating rounds (1148 treatment indications; 9-point scale) and three plenary discussion meetings. Results The panel reached agreement on 71% of treatment indications. 'No treatment' was never considered appropriate, and repeat treatment after previous failure was generally discouraged. For 98% of scenarios, at least one treatment was appropriate. Adjustment of IBD medication was deemed appropriate in all patients with active disease. Use of oral iron was mainly considered an option in NAID and mildly anaemic patients without disease activity. IV regimens were often judged appropriate, with high-dose IV iron being the preferred option in 77% of IDA scenarios. Blood transfusion and IV+ESA were indicated in exceptional cases only. Conclusions The RUAM revealed high agreement amongst experts on the management of iron deficiency in patients with IBD. High-dose IV iron was more often considered appropriate than other options. To facilitate dissemination of the recommendations, panel outcomes were embedded in an online tool, accessible via http://ferroscope.com/.
Год издания: 2013
Авторы: Walter Reinisch, Yehuda Chowers, Silvio Danese, Axel Dignaß, Fernando Gomollón, Ole Haagen Nielsen, Péter L. Lakatos, Charlie W. Lees, Stefan Lindgren, Milan Lukáš, Gerassimos J. Mantzaris, Pierre Michetti, Bjørn Moum, Laurent Peyrin‐Biroulet, Murat Törüner, C. Janneke van der Woude, Günter Weiß, Herman Stoevelaar
Издательство: Wiley
Источник: Alimentary Pharmacology & Therapeutics
Ключевые слова: Iron Metabolism and Disorders, Healthcare cost, quality, practices, Potassium and Related Disorders
Другие ссылки: Alimentary Pharmacology & Therapeutics (HTML)
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