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Effectiveness ofinfluenza vaccine inaging and olderadults: comprehensiveanalysis of theevidence Pierre Olivier LangMendèsSocquet2012 год

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence
review

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Abstract: Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals. Immunization is considered to be the cornerstone for preventing these adverse health outcomes, and vaccination programs are timed to optimize protection during the annual influenza season. Trivalent inactivated influenza virus vaccines are believed to be both effective and cost-saving; however, in spite of widespread influenza vaccination programs, rates of hospitalization for acute respiratory illness and cardiovascular diseases have been increasing in this population during recent annual influenza seasons. From meta-analyses summarizing estimates of influenza vaccine effectiveness from available observational clinical studies, this review aims to examine how effective current influenza vaccine strategies are in the aging and older adult population and to analyze which are the most important biases that interfere with measurements of influenza vaccine effectiveness. Furthermore, consideration is given to strategies that should be adopted in order to optimize influenza vaccine effectiveness in the face of immune exhaustion. Keywords: influenza vaccine effectiveness, influenza virus infection, immunosenescence, hemagglutinin activity inhibition, innate immunity, hemagglutinin inhibition, older adults
Год издания: 2012
Авторы: Pierre Olivier Lang, Mendès, Socquet, Assir, Govind Govind, Richard Aspinall
Издательство: Dove Medical Press
Источник: Clinical Interventions in Aging
Ключевые слова: Influenza Virus Research Studies, Respiratory viral infections research, SARS-CoV-2 and COVID-19 Research
Другие ссылки: Clinical Interventions in Aging (PDF)
Clinical Interventions in Aging (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
CERES (Cranfield University) (PDF)
CERES (Cranfield University) (HTML)
PubMed Central (HTML)
PubMed (HTML)