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Dextran SulfateSodium (DSS)‐InducedColitis in Mice Benoît ChassaingJ D AitkenMadhu Malleshappa2014 год

Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice
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Аннотация: Abstract Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis and Crohn's Disease, are complex and multifactorial diseases with unknown etiology. For the past 20 years, to study human IBD mechanistically, a number of murine models of colitis have been developed. These models are indispensable tools to decipher underlying mechanisms of IBD pathogenesis as well as to evaluate a number of potential therapeutics. Among various chemically induced colitis models, the dextran sulfate sodium (DSS)‐induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed. This protocol describes the DSS‐induced colitis model, focusing on details and factors that could affect DSS‐induced pathology. Curr. Protoc. Immunol . 104:15.25.1‐15.25.14. © 2014 by John Wiley & Sons, Inc.
Год издания: 2014
Авторы: Benoît Chassaing, J D Aitken, Madhu Malleshappa, Matam Vijay‐Kumar
Издательство: Wiley
Источник: Current Protocols in Immunology
Ключевые слова: Inflammatory Bowel Disease, Helicobacter pylori-related gastroenterology studies, Microscopic Colitis
Другие ссылки: Current Protocols in Immunology (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)