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Pathogenesis of BoneDiseases: The Role ofImmune System Giacomina BrunettiGiorgio MoriPatrizia D’Amelio2015 год

Pathogenesis of Bone Diseases: The Role of Immune System
редакционная статья

Полный текстСтраница публикацииПубликация в OpenAlex
Аннотация: Bone is a metabolically active tissue that undergoes continuous remodeling by two sequential events, bone formation and resorption. These events are strongly linked and tightly regulated to maintain skeletal homeostasis. The bone cells responsible for the dual events include the bone-resorbing cells, the osteoclasts, arising from monocyte-macrophage precursors, and the bone forming cells, the osteoblasts, having a mesenchymal origin. Immune and bone cell activities are linked by several pathways [1] and the former can promote bone building or destruction. Further, immune cells can be involved in the mineralization process occurring in extra-skeletal sites. In this special issue different authors highlighted these items both through research articles and reviews. In detail, interaction between osteoblast precursors, the mesenchymal stem cells (MSCs) [2], and immune cells during fracture repair acts as one of the key factors governing successful bone healing. Additionally, bone damage following immune deregulation may be local as in arthritis and periodontal disease (PD) or systemic as in osteoporosis [3] and osteotropic cancers [4, 5]. It could be multifactorial and thus due to genetic modifications (i.e., Gaucher disease) as well as to lipopolysaccharide- (LPS-) mediated release of inflammatory cytokines (i.e., PD, osteomyelitis, and arthritis), and so forth. New insights suggest that, in immune-mediated bone diseases, bone resorption active phases are characterized by increased levels of immunoreceptor tyrosine-based activation motifs (ITAMs); these molecules together with OSCAR could be indicative of disease progression. Further, osteotropic cancer-related immune alterations showed distinct immune cell phenotype as observed in chronic myeloid leukemia, multiple myeloma, and bone metastatic solid tumors. State-of-the-art and new mechanisms are clearly described in this special issue; they can be useful for the identification of new therapeutic targets and bone disease markers. Giacomina Brunetti Giorgio Mori Patrizia D'Amelio Roberta Faccio
Год издания: 2015
Авторы: Giacomina Brunetti, Giorgio Mori, Patrizia D’Amelio, Roberta Faccio
Издательство: Hindawi Publishing Corporation
Источник: Journal of Immunology Research
Ключевые слова: Bone Metabolism and Diseases, Cytokine Signaling Pathways and Interactions, Bone health and treatments
Другие ссылки: Journal of Immunology Research (PDF)
Journal of Immunology Research (HTML)
DOAJ (DOAJ: Directory of Open Access Journals) (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
Institutional Research Information System University of Turin (University of Turin) (PDF)
Institutional Research Information System University of Turin (University of Turin) (HTML)
Digital Commons - Becker (Washington University in St. Louis) (HTML)
PubMed Central (HTML)
PubMed (HTML)