Аннотация:Abstract Serious mental illnesses (SMIs) commonly co-occur with substance-use disorders and, if undetected and untreated, adversely affect their clinical course. This paper describes the use and scoring of the K6 scale, a brief and valid screening tool for SMI, in a large general population sample derived from the 2001 National Household Survey on Drug Abuse (NHSDA). Analyses examine the demographic characteristics and patterns of substance use disorders among persons with and without a co-occurring SMI.