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Validity of clinicalcase definitions forinfluenzasurveillance amonghospitalizedpatients: resultsfrom a ruralcommunity in NorthIndia Vivek GuptaFatimah S. DawoodK. Sanjay2012 год

Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India
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Аннотация: Objective: Clinical case definitions used for influenza surveillance among hospitalized patients vary and need systematic evaluation. Design, setting and sample: During July 2009–August 2011, we collected clinical data and specimens (nasal and throat swabs) from rural patients hospitalized for acute medical illnesses. Specimens were tested by rRT-PCR for influenza viruses. Main outcome measures: Case definitions evaluated the following: influenza-like illness (ILI: measured fever plus cough or sore throat); severe acute respiratory illness (SARI: ILI with difficulty breathing in ≥5 years, Integrated Management of Childhood Illness–defined pneumonia or severe pneumonia, or physician diagnosed lower respiratory infection in <5 years); acute respiratory infection (ARI: ≥1 of cough, nasal discharge, difficulty breathing or sore throat); febrile acute respiratory illness (FARI: fever plus either cough, sore throat, runny nose, difficulty breathing, or earache). Variants that included "reported fever" and additional sign–symptom combinations were also evaluated. Results: We enrolled 1043 hospitalized patients, including 257 children <5 years of age (range 1 day–86 years). Seventy-four patients tested influenza virus positive (including 28 A(H1N1)pdm09). Sensitivity(95% CI) and specificity (95% CI) for influenza infection were 78% (67–87) and 60% (57–63) for ILI (measured/reported fever); 37% (26–49) and 78% (75–80) for SARI (measured/reported fever); 82% (72–90) and 57% (54–60) for FARI (measured/reported fever); 88% (78–94) and 45% (42–49) for ARI; and 74% (63–84) and 61% (58–64) for measured/reported fever plus cough. Case definitions including only measured fever had lower sensitivity. Conclusion: ILI and FARI with measured/reported fever provided good balance between sensitivity and specificity among hospitalized patients. The simpler case definition of measured/reported fever plus cough is suited for field surveillance.
Год издания: 2012
Авторы: Vivek Gupta, Fatimah S. Dawood, K. Sanjay, Shobha Broor, Rajan Wigh, Akhilesh Mishra, Kathryn E. Lafond, Joshua A. Mott, Marc‐Alain Widdowson, Renu B. Lal, Anand Krishnan
Издательство: Wiley
Источник: Influenza and Other Respiratory Viruses
Ключевые слова: Influenza Virus Research Studies, Respiratory viral infections research, Pneumonia and Respiratory Infections
Другие ссылки: Influenza and Other Respiratory Viruses (PDF)
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Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)