База данных: Каталог библиотеки СФУ
Аннотация: <p>The emergence and widespread distribution of multidrug-resistant bacteria have raised serious public health concerns and led to significant negative impacts on clinical outcomes, healthcare costs, and public health strategies worldwide. The development of pharmaceuticals capable of effectively combating bacterial infections represents a significant challenge for contemporary medical science. In this article, delivery systems in the form of micro- and nanoparticles based on biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing novel 1-antipyryl-1<i>H</i>-pyrrol-2-one (NAP) were prepared and characterized in terms of their hydrodynamic size, zeta potential, surface morphology, encapsulation efficiency, drug loading, and structural characteristics. For particles possessing the best characteristics, in vitro drug release pattern, thermal properties, cytocompatibility with C2C12 myoblasts and hemolytic activity were determined. The obtained micro- and nanoparticles had regular spherical shape, average diameter of 1350–5763 nm (for microparticles) and 553–745 nm (for nanoparticles), and zeta potential ranging from − 43.9 mV to − 25.5 mV. The encapsulation of NAP into the PHBV matrix led to a decrease in degradation temperature and an increase in particle size, cold crystallization and glass transition temperatures in comparison with empty particles. The in vitro release study revealed that the release of NAP from PHBV particles followed the Fickian diffusion-controlled mechanism; the maximum cumulative amount of NAP (66.8%) in the studied medium was achieved in 120 h. Neither pristine NAP nor NAP-loaded PHBV microparticles influenced the metabolic activity and membrane integrity of C2C12 cells and caused haemoglobin leakage from human red blood cells (RBCs). Therefore, the obtained NAP-loaded PHBV microparticles may be suitable for sustained intramuscular delivery of NAP.</p>
Год издания: 2026
Авторы: Lipaikin Sergei Y. , Dorokhin Aleksei S. , Ryltseva Galina A. , Oberenko Andrey V. , Kiselev Evgeniy G. , Shabanov Alexander V. , Lyadov Vadim A. , Shavrina Nika V. , Terent'ev Alexander O. , Thomas Sabu , Volova Tatiana G. , Kessler Cathrine Издательство: Springer Science+Business Media B.V., Formerly Kluwer Academic Publishers B.V.
Источник: Journal of Polymers and the Environment
Выпуск: Т. 34, № 4
Держатель оригинала документа: Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS”, L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Mahatma Gandhi University, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Perm National Research Polytechnic University, Siberian Federal University, University of Johannesburg
Количество экземпляров: Твёрдая копия издания отсутствует в фонде библиотеки
Ключевые слова: polyhydroxyalkanoates, drug release, Cytocompatibility assay, polymeric microparticles, polymeric nanoparticles, Antipyrine drugs
Классификационные коды: ГРНТИ 31
ISSN: 1566-2543
