Cytokine Regulation and Oxidative Stress in Helicobacter Pylori-Associated Gastric Adenocarcinoma at Different Stages: Insights from a Cross-Sectional Study : научное издание
Библиографическое описание:Cytokine Regulation and Oxidative Stress in Helicobacter Pylori-Associated Gastric Adenocarcinoma at Different Stages: Insights from a Cross-Sectional Study : научное издание / O. Smirnova, A. Sinyakov, E. Kasparov. - Текст : непосредственный // International Journal of Molecular Sciences. - 2025. - Т. 26, № 15. - ISSN 1661-6596. - ISSN 1422-0067, DOI 10.3390/ijms26157609.
Аннотация:<jats:p>Gastric adenocarcinoma is a malignant tumor that develops from the glandular cells of the inner wall of the stomach. The prevalence of this type of disease varies from 90 to 95% of all types of gastric cancer. The aim of our study was to investigate the differences in the content of cytokines and oxidative stress markers in patients with gastric adenocarcinoma associated with H. pylori infection depending on the stage. The study included 281 patients with gastric cancer. At stage I of the disease—75 people, stage II—70 people, stage III—69 people, and stage IV of the disease—67 people. The levels of TNF-α, IL-2, IL-8, IFNγ, TNF-β, IL-17A, IL-6, IL-10, and IL-4 in the blood serum of patients and healthy individuals were determined by enzyme immunoassay and plasma oxidative stress scores (MDA, SOD, CAT, GST, GPO, CP). The present study revealed that H. pylori-infected gastric adenocarcinoma at different stages is associated with different plasma levels of cytokines, lipid peroxidation products, and antioxidant defense factors. Further studies are needed to evaluate the effectiveness of therapeutic strategies combining cytokine regulation and oxidative stress to improve clinical outcomes in gastric cancer.</jats:p>
Источник:International Journal of Molecular Sciences
Выпуск:Т. 26, № 15
Держатель оригинала документа:Federal Research Center “Krasnoyarsk Science Center”, Siberian Branch of the Russian Academy of Sciences “Scientific Research Institute of Medical Problems of the North”
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