Библиографическое описание:Esterification of Betulin 3-Acetate in Melts of the Maleic and Levulinic Acids : научное издание / V. A. Levdanskiy, N. V. Garyntseva, A. V. Levdanskiy. - Текст : непосредственный // Russian Journal of Bioorganic Chemistry. - 2024. - Т. 50, № 7. - P. 2918-2921. - The work was financially supported by the Russian Science Foundation Grant no. 23-23-00336 (https://rscf.ru/project/23-2300336/). - ISSN 1068-1620. - ISSN 1608-330X, DOI 10.1134/S106816202407029X.
Аннотация:<b>Objective:</b> Esters of betulin containing residues of bioactive aromatic and aliphatic acids are of interest to the chemical and pharmaceutical industry as hepatoprotectors, anti-inflammatory, antiulcer and immunomodulatory substances. The development of new efficient, ecological and economical methods for the synthesis of betulin esters is an urgent task. <b>Methods:</b> The structure of the resulting betulin esters was determined using IR and NMR spectroscopy, and the composition was determined by elemental analysis. <b>Results and Discussion:</b> A new “green” method for the production of betulin 3-acetate-28-maleate and betulin 3-acetate-28-levulinate has been developed. For the first time, esterification of betulin 3-acetate with melts of maleic acid and levulinic acids was carried out at a temperature of 185–200°C for 5–7 min to obtain betulin 3-acetate-28-maleate and betulin 3-acetate-28-levulinate, respectively. <b>Conclusions:</b> The advantages of the developed method for the synthesis of 3-acetate-28-maleate and 3-acetate-28-levulinate of betulin in comparison with the known ones are: the synthesis is carried out in the absence of harmful and hazardous solvents (pyridine, methylene chloride, chloroform); the duration of synthesis is reduced from 15–40 h to 5–7 min. Maleic acid is used instead of maleic anhydride on the preparation of betulin 3-acetate-28-maleate.
Держатель оригинала документа:Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center KSC SB RAS, Krasnoyarsk State Agrarian University
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