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Magnetomechanicalstimulation of bonetissue regeneration :научное издание Zamay G.S.Kolovskaya O.S.Grek D.S.2021 год

Magnetomechanical stimulation of bone tissue regeneration : научное издание
статья из журнала

Дополнительные ссылки: eLibrary
База данных: Каталог библиотеки СФУ
Библиографическое описание: Magnetomechanical stimulation of bone tissue regeneration : научное издание / G. S. Zamay [и др.]. - Текст : непосредственный // Сибирское медицинское обозрение. - 2021. - № 2. - С. 90-93. - ISSN 1819-9496. - ISSN 2500-0136, DOI 10.20333/25000136-2021-2-90-93.
Аннотация: <jats:p>The aim of the research. To assess the ability of superparamagnetic nanoparticles functionalized with the RGD peptide to accelerate bone tissue recovery aft er transverse osteotomy under the infl uence of a low-frequency alternating magnetic fi eld. Material and methods. We used superparamagnetic nanoparticles ferroarabinogalactans (FeAG) functionalized with the RGD peptide for targeted binding to integrins. Th e model for assessing the ability of FeAG-RGD to accelerate bone regeneration was the transverse osteotomy of the radius of the ICR mice. To induce the process of bone tissue regeneration aft er the injection of FeAG-RGD particles, mice were placed in an alternating magnetic fi eld (50 Hz 100 Oe) for 60 min. Th e therapy was performed daily for 5 days. Results. Th e paper tested the hypothesis about the acceleration of bone tissue regeneration by the method of magnetomechanical therapy using superparamagnetic FeAG-RGD nanoparticles. It has been established that FeAG-RGD under conditions of an alternating magnetic fi eld (50 Hz 100 Oe) are able to change their orientation in space and, thus, cause mechanical stress in the proteins of the cell membrane – integrins, which trigger the process of osteogenic diff erentiation. Th e research results showed that 5 procedures of magnetomechanical therapy lead to complete restoration of bone tissue at the site of the transverse osteotomy, while in the group of control animals no fusion of bones is observed. Conclusion. Th e use of the method of magnetomechanical therapy using ferroarabinogalactans functionalized with the targeting ligand RGD for binding to integrins of osteogenic cells is a promising technology for bone tissue regeneration</jats:p>
Год издания: 2021
Авторы: Zamay G.S., Kolovskaya O.S., Grek D.S., Babkin V.A., Neverova N.A., Koshmanova A.A., Patc Yu.S.
Издательство: Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого, Красноярск
Источник: Сибирское медицинское обозрение
Выпуск: № 2
Номера страниц: 90-93
Количество экземпляров:
Твёрдая копия издания отсутствует в фонде библиотеки

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