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Information Load fromNeuromediatorDiffusion toExtrasynaptic Space:The Interplay betweenthe InjectionFrequency andClearance… : научноеиздание Shuvaev AndreyBelozor OlgaShuvaev Anton2024 год

Information Load from Neuromediator Diffusion to Extrasynaptic Space: The Interplay between the Injection Frequency and Clearance : научное издание
статья из журнала

Дополнительные ссылки: eLibrary
База данных: Каталог библиотеки СФУ
Библиографическое описание: Information Load from Neuromediator Diffusion to Extrasynaptic Space: The Interplay between the Injection Frequency and Clearance : научное издание / A. A. Shuvaev, O. O. Belozor, A. A. Shuvaev. - Текст : непосредственный // Biology. - 2024. - Т. 13, № 8. - P. 566. - ISSN 2079-7737, DOI 10.3390/biology13080566.
Аннотация: <jats:p>In our study, we simulate the release of glutamate, a neurotransmitter, from the presynaptic cell by modeling the diffusion of glutamate into both synaptic and extrasynaptic space around the synapse. We have also incorporated a new factor into our model: convection. This factor represents the process by which the body clears glutamate from the synapse. Due to this process, the physiological mechanisms that typically prevent glutamate from spreading beyond the synapse are altered. This results in a different distribution of glutamate concentrations, with higher levels outside the synapse than inside it. The variety of biological effects that occur in response to this extrasynaptic glutamate highlights the importance of preventing neurotransmitters from spreading beyond the synapse. We aim to explain the physical reasons behind these biological effects, which are observed as excitotoxicity. Our results show that preventing the spread of glutamate outside the synapse increases the amount of information exchanged within the synapse and its surroundings for frequencies of glutamate release up to 30–50 Hz, followed by a decrease. Additionally, we find that the rate at which glutamate is cleared from the synapse is effective at relatively low levels (≤0.5 nm/μs in our calculation grid) and remains constant at higher levels.</jats:p>
Год издания: 2024
Авторы: Shuvaev Andrey , Belozor Olga , Shuvaev Anton
Издательство: MDPI AG
Источник: Biology
Выпуск: Т. 13, № 8
Номера страниц: 566
Держатель оригинала документа: Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia, Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
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