N-Silylmethyl-2-(1-Naphthyl)Acetamides: Synthesis, Structure and Computational Screening

Soldatenko Anastasiya S.; Molokeev Maxim S.; Lazareva Nataliya F.

Дополнительные ссылки: eLibrary

База данных: Каталог библиотеки СФУ

Библиографическое описание: N-Silylmethyl-2-(1-Naphthyl)Acetamides: Synthesis, Structure and Computational Screening : научное издание / Anastasiya S. Soldatenko, Maxim S. Molokeev, Nataliya F. Lazareva. - Текст : непосредственный // Current Organic Chemistry. - 2024. - Т. 28, № 12. - P. 959-966. - ISSN 1385-2728. - ISSN 1875-5348, DOI 10.2174/0113852728296495240409062733.

Аннотация: Abstract: Synthesis of new hybrid organosilicon compounds based on the amides 1- naphthylacetic acid was described. N-Organyl-2-(1-naphthyl)-N-[(triethoxysilyl)methyl]- acetamides were obtained by the reaction of 1-naphthylacetyl chloride with α-silylamines RNHCH2Si(OEt)3 (R = Me, i-Pr and Ph). Their subsequent interaction with N(CH2CH2OH)3 led to the formation of N-organyl-2-(1-naphthyl)-N-(silatranylmethyl)acetamides. The structure of these hybrid compounds was characterized by 1H, 13C, and 29Si NMR spectroscopy. The structure of N-methyl- and N-isopropyl-2-(1-naphthyl)-N-(silatranylmethy)acetamides was confirmed by X-ray diffraction analysis. Results of computational screening showed that these silatranes are bioavailable and have drug-likeness.

Год издания: 2024

Авторы: Soldatenko Anastasiya S. , Molokeev Maxim S. , Lazareva Nataliya F.

Издательство: Bentham Science Publishers

Источник: Current Organic Chemistry

Выпуск: Т. 28, № 12

Номера страниц: 959-966

Держатель оригинала документа: Institute of Engineering Physics and Radio Electronic, Siberian Federal University, Krasnoyarsk 660041, Russia, Laboratory of Crystal Physics, Federal Research Center KSC SB RAS, Kirensky Institute of Physics, Krasnoyarsk 660036, Russia, Siberian Division of the Russian Academy of Sciences, A.E. Favorsky Irkutsk Institute of Chemistry, 1 Favorsky Street, Irkutsk 664033, Russia

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N-Silylmethyl-2-(1-Naphthyl)Acetamides: Synthesis, Structure and Computational Screening
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