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Effects of iron oxidenanoparticles on thegene expressionprofiles of cerebralendotheliocytes andastrocytes Tyumentseva AnnaKhilazheva ElenaPetrova Valeria2024 год

Effects of iron oxide nanoparticles on the gene expression profiles of cerebral endotheliocytes and astrocytes
статья из журнала

Дополнительные ссылки: eLibrary
База данных: Каталог библиотеки СФУ
Библиографическое описание: Effects of iron oxide nanoparticles on the gene expression profiles of cerebral endotheliocytes and astrocytes : научное издание / A. A. Tyumentseva [et al.]. - Текст : непосредственный // Toxicology in Vitro. - 2024. - Т. 98, № . - P. 105829. - ISSN 0887-2333, DOI 10.1016/j.tiv.2024.105829.
Аннотация: Iron oxide nanoparticles (IONPs) are considered as the most biocompatible magnetic materials suitable for biomedical applications. Nevertheless, there are many evidences of their toxicity for living organisms and partially neurotoxicity. The central nervous system is protected from undesirable substances circulating in the bloodstream by the blood-brain barrier (BBB). And even if being small enough, some nanoparticles could be able to penetrate cell membranes in other cells but will often be delayed by the BBB cells. However, the neurotoxicity of iron oxide is described even in the cases when IONPs should not uptake to the nervous system by experimental design. The aim of this study was to investigate what molecular changes in the cells-components of BBB - endotheliocytes and underlying astrocytes - may be caused by IONPs in the blood vessels of the brain. For this, a two-layer in vitro BBB model was created, consisting of rat cerebral endothelial cells and astrocytes. It was revealed that 100 and 200 mg/L of the nanoparticles induce metabolism alteration in the cells under study. Using RNA-sequencing, the up-regulation of pro-inflammatory chemokines encoding genes and changes in the expression of genes associated with detoxification in the endotheliocytes were demonstrated under the influence of 100 mg/L IONPs.
Год издания: 2024
Авторы: Tyumentseva Anna , Khilazheva Elena , Petrova Valeria , Stolyar Sergey
Издательство: Elsevier Science Publishing Company, Inc.
Источник: Toxicology in Vitro
Выпуск: Т. 98
Номера страниц: 105829
Держатель оригинала документа: Federal Research Center, Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Ministry of Health of the Russian Federation
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