1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Unraveling thefunctional darkmatter through globalmetagenomics :научное издание Pavlopoulos Georgios A.Baltoumas Fotis A.Liu Sirui2023 год

Unraveling the functional dark matter through global metagenomics : научное издание
статья из журнала

Дополнительные ссылки: eLibrary
База данных: Каталог библиотеки СФУ
Библиографическое описание: Unraveling the functional dark matter through global metagenomics : научное издание / Georgios A. Pavlopoulos [et al.]. - Текст : непосредственный // Nature. - 2023. - Т. 622, № 7983. - P. 594-602. - ISSN 0028-0836. - ISSN 1476-4687, DOI 10.1038/s41586-023-06583-7.
Аннотация: <jats:title>Abstract</jats:title><jats:p>Metagenomes encode an enormous diversity of proteins, reflecting a multiplicity of functions and activities<jats:sup>1,2</jats:sup>. Exploration of this vast sequence space has been limited to a comparative analysis against reference microbial genomes and protein families derived from those genomes. Here, to examine the scale of yet untapped functional diversity beyond what is currently possible through the lens of reference genomes, we develop a computational approach to generate reference-free protein families from the sequence space in metagenomes. We analyse 26,931 metagenomes and identify 1.17 billion protein sequences longer than 35 amino acids with no similarity to any sequences from 102,491 reference genomes or the Pfam database<jats:sup>3</jats:sup>. Using massively parallel graph-based clustering, we group these proteins into 106,198 novel sequence clusters with more than 100 members, doubling the number of protein families obtained from the reference genomes clustered using the same approach. We annotate these families on the basis of their taxonomic, habitat, geographical and gene neighbourhood distributions and, where sufficient sequence diversity is available, predict protein three-dimensional models, revealing novel structures. Overall, our results uncover an enormously diverse functional space, highlighting the importance of further exploring the microbial functional dark matter.</jats:p>
Год издания: 2023
Авторы: Pavlopoulos Georgios A., Baltoumas Fotis A., Liu Sirui, Selvitopi Oguz, Camargo Antonio Pedro, Nayfach Stephen, Azad Ariful, Roux Simon, Call Lee, Ivanova Natalia N., Chen I. Min, Paez-Espino David, Karatzas Evangelos, Acinas Silvia G., Ahlgren Nathan, Attwood Graeme, Baldrian Petr, Berry Timothy, Bhatnagar Jennifer M., Bhaya Devaki, Bidle Kay D., Blanchard Jeffrey L., Boyd Eric S., Bowen Jennifer L., Bowman Jeff, Brawley Susan H., Brodie Eoin L., Brune Andreas, Bryant Donald A., Buchan Alison, Cadillo-Quiroz Hinsby, Campbell Barbara J., Cavicchioli Ricardo, Chuckran Peter F., Coleman Maureen, Crowe Sean, Colman Daniel R., Currie Cameron R., Dangl Jeff, Delherbe Nathalie, Denef Vincent J., Dijkstra Paul, Distel Daniel D., Eloe-Fadrosh Emiley, Fisher Kirsten, Francis Christopher, Garoutte Aaron, Gaudin Amelie, Gerwick Lena, Godoy-Vitorino Filipa, Guerra Peter, Guo Jiarong, Habteselassie Mussie Y., Hallam Steven J., Hatzenpichler Roland, Hentschel Ute, Hess Matthias, Hirsch Ann M., Hug Laura A., Hultman Jenni, Hunt Dana E., Huntemann Marcel, Inskeep William P., James Timothy Y., Jansson Janet, Johnston Eric R., Kalyuzhnaya Marina, Kelly Charlene N., Kelly Robert M., Klassen Jonathan L., Nüsslein Klaus, Kostka Joel E., Lindow Steven, Lilleskov Erik, Lynes Mackenzie, Mackelprang Rachel, Martin Francis M., Mason Olivia U., McKay R. Michael, McMahon Katherine, Mead David A., Medina Monica, Meredith Laura K., Mock Thomas, Mohn William W., Moran Mary Ann, Murray Alison, Neufeld Josh D., Neumann Rebecca, Norton Jeanette M., Partida-Martinez Laila P., Pietrasiak Nicole, Pelletier Dale, Reddy T. B. K., Reese Brandi Kiel, Reichart Nicholas J., Reiss Rebecca, Saito Mak A., Schachtman Daniel P., Seshadri Rekha, Shade Ashley, Sherman David, Simister Rachel, Simon Holly, Stegen James, Stepanauskas Ramunas, Sullivan Matthew, Sumner Dawn Y., Teeling Hanno, Thamatrakoln Kimberlee, Treseder Kathleen, Tringe Susannah, Vaishampayan Parag, Valentine David L., Waldo Nicholas B., Waldrop Mark P., Walsh David A., Ward David M., Wilkins Michael, Whitman Thea, Woolet Jamie, Woyke Tanja, Iliopoulos Ioannis, Konstantinidis Konstantinos, Tiedje James M., Pett-Ridge Jennifer, Baker David, Visel Axel, Ouzounis Christos A., Ovchinnikov Sergey, Buluç Aydin, Kyrpides Nikos C.
Издательство: Springer Nature
Источник: Nature
Выпуск: Т. 622, № 7983
Номера страниц: 594-602
Держатель оригинала документа: Novel Metagenome Protein Families Consortium
Количество экземпляров:
Твёрдая копия издания отсутствует в фонде библиотеки

Похожие публикации

What is dark matter? / : библиография

  • Fisher Peter
  • 2022 год

The elephant in the universe : our hundred-year search for dark matter

  • Schilling Govert
  • 2022 год

Dark matter credit : the development of peer-to-peer lending and banking in France

  • Hoffman Philip T.
  • 2019 год
Albic Podzols ofBoreal Pine Forestsof Russia: SoilOrganic Matter,Physicochemical andMicrobiologicalProperties… Dymov Alexey A.Grodnitskaya Irina D.Yakovleva Evgenia V.2022 год

Albic Podzols of Boreal Pine Forests of Russia: Soil Organic Matter, Physicochemical and… : научное издание

  • Dymov Alexey A. и др.
  • 2022 год
Global patterns andenvironmental driversof forest functionalcomposition Bouchard EliseSearle Eric B.Drapeau Pierre2024 год

Global patterns and environmental drivers of forest functional composition : статья из журнала

  • Bouchard Elise и др.
  • 2024 год

Dark data: why what you don't know matters : научное издание

  • Hand David J.
Differences inorganic matter andbacterioplanktonbetween sections ofthe largest Arcticriver: Mosaic orcontinuum? Gladyshev M.I.Glushchenko L.A.Kolmakova O.V.2015 год

Differences in organic matter and bacterioplankton between sections of the largest Arctic river:… : статья из журнала

  • Gladyshev M.I. и др.
  • 2015 год
Albic Podzols ofBoreal Pine Forestsof Russia: SoilOrganic Matter,Physicochemical andMicrobiologicalProperties… Dymov A.A.Grodnitskaya I.D.Yakovleva E.V.2022 год

Albic Podzols of Boreal Pine Forests of Russia: Soil Organic Matter, Physicochemical and… : статья из журнала

  • Dymov A.A. и др.
  • 2022 год

Показать ещё

Membranes to molecular machines : active matter and the remaking of life /

  • Grote Mathias
  • 2019 год
The relationshipbetween the molecularcomposition of coaland the conversion ofits organic matterduring thermal… Safin V.A.Kuznetsov P.N.Kuznetsova L.I.2022 год

The relationship between the molecular composition of coal and the conversion of its organic matter… : научное издание

  • Safin V.A. и др.
  • 2022 год
Enhancing physicaland functionalfitness through theintegration of healthfitness elements inyoung gymnasts Romanova E.V.Vorozheikin A.V.Bayankin O.V.2023 год

Enhancing physical and functional fitness through the integration of health fitness elements in… : статья из журнала

  • Romanova E.V. и др.
  • 2023 год
The globaldistribution anddrivers of wooddensity and theirimpact on forestcarbon stocks Mo LidongCrowther Thomas W.Maynard Daniel S.2024 год

The global distribution and drivers of wood density and their impact on forest carbon stocks : научное издание

  • Mo Lidong и др.
  • 2024 год
Evenness mediates theglobal relationshipbetween forestproductivity andrichness Hordijk IrisMaynard Daniel S.Hart Simon P.2023 год

Evenness mediates the global relationship between forest productivity and richness : статья из журнала

  • Hordijk Iris и др.
  • 2023 год
Design andperformance of theClimate ChangeInitiative Biomassglobal retrievalalgorithm Santoro MaurizioCartus OliverQuegan Shaun2024 год

Design and performance of the Climate Change Initiative Biomass global retrieval algorithm : статья из журнала

  • Santoro Maurizio и др.
  • 2024 год
Functional symmetryand reproducibilityof the evolutionaryprocess Bartsev S. I.2026 год

Functional symmetry and reproducibility of the evolutionary process : научное издание

  • Bartsev S. I.
  • 2026 год

Why birds matter : avian ecological function and ecosystem services /

  • S̜ekercioğlu, C̜ağan, и др.
  • 2016 год