Библиографическое описание:Characteristics of Microparticles Based on Resorbable Polyhydroxyalkanoates Loaded with Antibacterial and Cytostatic Drugs : научное издание / Anastasiya V. Murueva [et al.]. - Текст : непосредственный // International Journal of Molecular Sciences. - 2023. - Т.24, №19. - P. 14983. - ISSN 1661-6596. - ISSN 1422-0067, DOI 10.3390/ijms241914983.
Аннотация:<jats:p>The development of controlled drug delivery systems, in the form of microparticles, is an important area of experimental pharmacology. The success of the design and the quality of the obtained microparticles are determined by the method of manufacture and the properties of the material used as a carrier. The goal is to obtain and characterize microparticles depending on their method of preparation, the chemical composition of the polymer and the load of the drugs. To obtain microparticles, four types of degradable PHAs, differing in their chemical compositions, degrees of crystallinity, molecular weights and temperature characteristics, were used (poly-3-hydroxybutyrate and copolymers 3-hydroxybutyric-co-3-hydroxyvaleric acid, 3-hydroxybutyric-co-4-hydroxybutyric acid, and 3-hydroxybutyric-co-3-hydroxyhexanoic acid). The characteristics of microparticles from PHAs were studied. Good-quality particles with an average particle diameter from 0.8 to 65.0 μm, having satisfactory ζ potential values (from −18 to −50 mV), were obtained. The drug loading content, encapsulation efficiency and in vitro release were characterized. Composite microparticles based on PHAs with additives of polyethylene glycol and polylactide-co-glycolide, and loaded with ceftriaxone and 5-fluorouracil, showed antibacterial and antitumor effects in E. coli and HeLa cultures. The results indicate the high potential of PHAs for the design of modern and efficient drug delivery systems.</jats:p>
Источник:International Journal of Molecular Sciences
Выпуск:Т.24, №19
Номера страниц:14983
Держатель оригинала документа:Chemistry Engineering Centre, ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint Petersburg, Russia, Institute of Biophysics SB RAS, Federal Research Center “Krasnoyarsk Science Center SB RAS” (IBP SB RAS), 50/50 Akademgorodok, 660036 Krasnoyarsk, Russia, Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 79 Svobodny Pr., 660041 Krasnoyarsk, Russia
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