Determination of the Stability Constants of Supramolecular Complexes of Ester Derivatives of Betulin with Randomly Methylated β-Cyclodextrin by Affinity Capillary Electrophoresis : научное издание
Библиографическое описание:Determination of the Stability Constants of Supramolecular Complexes of Ester Derivatives of Betulin with Randomly Methylated β-Cyclodextrin by Affinity Capillary Electrophoresis : научное издание / V. V. Sursyakova, V. A. Levdansky, A. I. Rubaylo. - Текст : непосредственный // Russian Journal of Physical Chemistry A. - 2023. - Т.97, №10. - P. 2225-2230. - This work was conducted within the framework of the budget project no. FWES-2021-0012 (registration no. 121031500209-6 in Unified State Accounting Information System of Research, Development, and Technological Work for Civil Purposes (EGISU NIOKTR)) for Institute of Chemistry and Chemical Technology SB RAS using the equipment of Krasnoyarsk Regional Research Equipment Centre of FRC KSC SB RAS. - ISSN 0036-0244. - ISSN 1531-863X, DOI 10.1134/S0036024423100230.
Аннотация:Using affinity capillary electrophoresis, the stability constants of inclusion complexes of a number of betulin ester derivatives with randomly methylated β-cyclodextrin in 0.0100 M sodium tetraborate (pH 9.18, ionic strength 0.0200 M) at 25°С were determined for the first time. The decimal logarithms of the stability constants of 1 : 1 complexes of betulin 3,28-diphthalate, betulin 3,28-disulfate, and betulin 3,28-disuccinate in a 95% confidence interval were 4.64 ± 0.05, 4.78 ± 0.02, and 4.94 ± 0.02, respectively. The logarithms of the stability constants of 1 : 2 complexes of betulin 3,28-diphthalate and betulin 3,28-disulfate were 7.91 (6.66–8.19) and 8.02 (7.63–8.23), respectively. It was determined that betulin 3,28-disuccinate forms only 1 : 1 complex. The obtained stability constants of 1 : 1 complexes are generally higher than those of the complexes of the same compounds with β-cyclodextrin (β-CD) and lower than those for dimethyl-β-CD, γ-CD, and (2-hydroxypropyl)-γ-CD complexes.
Держатель оригинала документа:Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences, Siberian Federal University
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