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Cover Feature:Structure- andInteraction-BasedDesign ofAnti-SARS-CoV-2Aptamers (Chem. Eur.J. 12/2022) : научноеиздание Mironov VladimirShchugoreva Irina A.Artyushenko Polina V.2022 год

Cover Feature: Structure- and Interaction-Based Design of Anti-SARS-CoV-2 Aptamers (Chem. Eur. J. 12/2022) : научное издание
статья из журнала

База данных: Каталог библиотеки СФУ
Аннотация: Digital drug design reveals DNA aptamers binding SARS-CoV-2: A hybrid in silico et vitro approach, structure and interaction-based drug design, has been developed to create highly specific DNA aptamers for the receptor-binding domain of the SARS-CoV-2 spike protein. The structure and binding affinity of the aptamers were validated by small-angle X-ray scattering, flow cytometry, and fluorescence polarization. This approach offers a blueprint for the straightforward design of targeting molecules for new pathogens and emerging variants. More information can be found in the Research Article by Y. Alexeev, M. V. Berezovski, A. S. Kichkailo, et al. (DOI: 10.1002/chem.202104481).
Год издания: 2022
Авторы: Mironov Vladimir, Shchugoreva Irina A., Artyushenko Polina V., Morozov Dmitry, Borbone Nicola, Oliviero Giorgia, Zamay Tatiana N., Moryachkov Roman V., Kolovskaya Olga S., Lukyanenko Kirill A., Song Yanling, Merkuleva Iuliia A., Zabluda Vladimir N., Peters Georgy, Koroleva Lyudmila S., Veprintsev Dmitry V., Glazyrin Yury E., Volosnikova Ekaterina A., Belenkaya Svetlana V., Esina Tatiana I., Isaeva Anastasiya A., Nesmeyanova Valentina S., Shanshin Daniil V., Berlina Anna N., Komova Nadezhda S., Svetlichnyi Valery A., Silnikov Vladimir N., Shcherbakov Dmitriy N., Zamay Galina S., Zamay Sergey S., Smolyarova Tatyana, Tikhonova Elena P., Chen Kelvin H.-C., Jeng U-Ser, Condorelli Gerolama, de Franciscis Vittorio, Groenhof Gerrit, Yang Chaoyong, Moskovsky Alexander A., Fedorov Dmitri G., Tomilin Felix N., Tan Weihong, Alexeev Yuri, Berezovski Maxim V., Kichkailo Anna S.
Источник: Chemistry

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