1. Главная
  2. Ресурсы
  3. Библиотечный поиск
Towards understandingthe triggering of themalignant cell deathin high-efficiencymagneto-mechanicalanticancer therapy Semina P.N.Isaev I.L.Komogortsev S.V.2023 год

Towards understanding the triggering of the malignant cell death in high-efficiency magneto-mechanical anticancer therapy : научное издание
статья из журнала

Дополнительные ссылки: eLibrary
База данных: Каталог библиотеки СФУ
Библиографическое описание: Towards understanding the triggering of the malignant cell death in high-efficiency magneto-mechanical anticancer therapy : научное издание / P. N. Semina [et al.]. - Текст : непосредственный // Journal of Physics D: Applied Physics. - 2023. - Т.56, №6. - P. 065401. - ISSN 0022-3727. - ISSN 1361-6463, DOI 10.1088/1361-6463/acb0dd.
Аннотация: The paper discusses schemes for implementing magneto-mechanical anticancer therapy and the most probable scenarios of damaging mechanical effects on the membranes of malignant cells by targeted magnetic nanoparticles (MNPs) selectively bound to membrane mechanoreceptors employing aptamers. The conditions for the selective triggering of the malignant cell apoptosis in a low-frequency non-heating alternating magnetic field, corresponding to the exceeding threshold value of the force acting on the membrane and its mechanoreceptors, are established using a nanoparticle dynamic simulation. The requirements for the functionality of MNPs and their suitability for biomedical applications are analyzed. Attention is paid to the possibility of the formation of magnetite nanoparticle aggregates in an external magnetic field and their localization near tumor cell membranes. It is shown that the scenario involving the process of aggregation of magnetite nanoparticles provides a sufficient magneto-mechanical impact to achieve a therapeutic effect. A possible explanation for the experimentally established fact of successful application of magneto-mechanical therapy using magnetite nanoparticles is presented, in which complete suppression of the Ehrlich carcinoma in an alternating magnetic field as a response to a magneto-mechanical stimulus was demonstrated. This result confirmed the possibility of using the method for high efficiency treatment of malignant neoplasms. The paper provides an extensive review of key publications and the state of the art in this area.
Год издания: 2023
Авторы: Semina P.N. , Isaev I.L. , Komogortsev S.V. , Kluchantsev A.B., Kostykov A.S. , Blagodatova A.V. , Khrennikov D.E. , Kichkailo A.S. , Zamay T.N. , Lapin I.N. , Sokolov A.E. , Polyutov S.P. , Karpov S.V.
Издательство: Institute of Physics and IOP Publishing Limited
Источник: Journal of Physics D: Applied Physics
Выпуск: Т.56, №6
Номера страниц: 065401
Держатель оригинала документа: Federal Research Center "Krasnoyarsk Science Center" of the Siberian Branch of the Russian Academy of Sciences, Federal Research Center KSC the Siberian Branch of the Russian Academy of Sciences, Federal Siberian Research Clinical Center, Institute of Computational Modelling of the Siberian Branch of the Russian Academy of Sciences, Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Siberian Federal University, Tomsk State University
Количество экземпляров:
Твёрдая копия издания отсутствует в фонде библиотеки

Похожие публикации

Understanding the Secular in the Philosophical Tradition of the Vekhi Group : статья из журнала

  • Shchipkov Vasiliy
  • 2023 год

The Other of Sonya Marmeladova in F. M. Dostoevsky`s Novel. A New Understanding of Ambivalence : статья из журнала

  • Urazayeva Kuralay и др.
  • 2026 год

New Approaches to Understanding the Problem of a Choice Phenomenon : статья из журнала

  • Vasil`eva Nina
  • 2016 год

New Understanding of Time Based on the Concept of Areal Multitudes : статья из журнала

  • Poluyan Pavel
  • 2015 год

The Problem of Understanding in the Works of D. Kharms (Based on the Collection "Incidents") : статья из журнала

  • Kovtun Natalia и др.
  • 2016 год
Technology andgender: Understandingthe changing dynamicsof femaleunemployment in theG7 countries Cil MelekGuzey Yildiz Yilmaz2024 год

Technology and gender: Understanding the changing dynamics of female unemployment in the G7… : статья из журнала

  • Cil Melek и др.
  • 2024 год
Pan-EurasianExperiment (PEEX):Towards a holisticunderstanding of thefeedbacks andinteractions in theland… Lappalainen H.K.Kerminen V.M.Petäjä T.2016 год

Pan-Eurasian Experiment (PEEX): Towards a holistic understanding of the feedbacks and interactions… : научное издание

  • Lappalainen H.K. и др.
  • 2016 год
The Other of SonyaMarmeladova in F. M.Dostoevsky’s Novel. ANew Understanding ofAmbivalence Urazayeva Kuralay B.Turzhanova Tamara N.Razumovskaya Veronica A.2026 год

The Other of Sonya Marmeladova in F. M. Dostoevsky’s Novel. A New Understanding of Ambivalence : научное издание

  • Urazayeva Kuralay B. и др.
  • 2026 год

Показать ещё

Attitudes towarddeath and thereligiousconsciousness ofyouth Fenvesh T.A.Andreeva A.V.Pavlov A.P.2019 год

Attitudes toward death and the religious consciousness of youth : статья из журнала

  • Fenvesh T.A. и др.
  • 2019 год
Towards understandingthe cathode processmechanism andkinetics in moltenlif–alf3 during thetreatment of spentpt… Yasinskiy AndreyPadamata Sai KrishnaStopic Srecko2021 год

Towards understanding the cathode process mechanism and kinetics in molten lif–alf3 during the… : статья из журнала

  • Yasinskiy Andrey и др.
  • 2021 год
The rationale forincreasing thetheoreticalunderstanding on thebasic concepts ofeconomic theory Vasilyev E.P.Filimonenko I.V.Likhacheva T.P.2017 год

The rationale for increasing the theoretical understanding on the basic concepts of economic theory : научное издание

  • Vasilyev E.P. и др.
  • 2017 год
Understanding theEnergy Barriers ofthe Reversible IonExchange Process inCsPbBr1.5Cl1.5@Y2O3:Eu3+Macroporous… Li M.Zhao Y.Zhang S.2021 год

Understanding the Energy Barriers of the Reversible Ion Exchange Process in CsPbBr1.5Cl1.5@Y2O3:Eu3… : научное издание

  • Li M. и др.
  • 2021 год

Understanding global climate change : modelling the climatic system and human impacts

  • Cracknell Arthur P. и др.
  • 2021 год

The Revival of Psychological Anthropology: a New Understanding of Interrelation Between Cultural… : статья из журнала

  • Lourie Svetlana
  • 2017 год
Understanding theeffect of structuraldefects in graphiteon the properties offoundry coatings Illarionov I.E.Gilmanshina T.R.Kovaleva A.A.2018 год

Understanding the effect of structural defects in graphite on the properties of foundry coatings : статья из журнала

  • Illarionov I.E. и др.
  • 2018 год
The Problem ofUnderstanding in theWorks of D. Kharms(Based on theCollection"Incidents") Kovtun Natalia V.Skripnikova Uliana A.2016 год

The Problem of Understanding in the Works of D. Kharms (Based on the Collection "Incidents") : статья из журнала

  • Kovtun Natalia V. и др.
  • 2016 год