Библиографическое описание:Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors : научное издание / T. T. Zamay [et al.]. - Текст : непосредственный // Journal of Functional Biomaterials. - 2023. - Т. 14, № 4. - P. 179. - ISSN 2079-4983, DOI 10.3390/jfb14040179.
Аннотация:One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi- dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square- shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.
Держатель оригинала документа:Far Eastern Federal University, Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch, Russian Academy of Sciences, Institute of Automation and Control Processes (IACP), Far Eastern Branch of the Russian Academy of Science, JSC «NPP «Radiosviaz», L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Siberian Physical Technical Institute,Tomsk State University, V.P. Astafiev Krasnoyarsk State Pedagogical University
Количество экземпляров:
Твёрдая копия издания отсутствует в фонде библиотеки
