Association of the plasma levels and gene polymorphism IL12B, IL13 with severe asthma in Siberian children : научное издание

Smolnikova M.V.; Smirnova Svetlana; Tereshchenko Sergey; Gorbacheva Nina; Konopleva Olga; Belenjuk Vasiliy

Дополнительные ссылки: eLibrary

База данных: Каталог библиотеки СФУ

Библиографическое описание: Association of the plasma levels and gene polymorphism IL12B, IL13 with severe asthma in Siberian children : научное издание / M. V. Smolnikova, S. Smirnova, S. Tereshchenko [et al.]. - Текст : непосредственный // European Respiratory Journal, Supplement. - 2021. - Т. 58, № S65. -PA3078. - ISSN 0904-1850, DOI 10.1183/13993003.congress-2021.PA3078.

Аннотация: The phenotype of the disease and the asthma severity can be affected by a genetically mediated level of cytokine concentration. The aim of the work was to study the plasma level of the IL-12B and IL-13 and the distribution of the IL12B rs3212220 and IL13 rs1800925 genotypes. Methods: Children with asthma were studied: mild severity (n=133), moderate (n=102) and severe (n=82). Control group was represented by healthy individuals (n=229). The plasma level of cytokines was measured using the Milliplex Panel (Millipore, USA). Genotyping was carried out by RT-PCR. Results: The T* allele rs321220 occurs rather less frequently in moderate asthma individuals (OR 0.63 (0.41-0.97), p=0.035), with it having been assumed its protective role to the disease, whereas the G* allele is predisposing to severe asthma. Allele T* rs1800925 IL13 is more common in patients, whatever the disease severity as related to the control (p=0.01). The significant differences of the plasma level IL-12B in the general cohort of patients with asthma, depending on the IL12B rs321220 genotype were revealed. The plasma level of IL-13 is higher in the CT and TT IL13 rs1800925 genotypes, than in carriers of the CC genotype (Fig.1). Conclusion: We have identified the genetic markers for susceptibility to asthma in Siberian children, i.e. allele G IL12B rs321220 and allele T IL13 rs1800925 are predisposing to severe asthma.

Год издания: 2021

Авторы: Smolnikova M.V. , Smirnova Svetlana , Tereshchenko Sergey , Gorbacheva Nina , Konopleva Olga , Belenjuk Vasiliy

Издательство: European Respiratory Society

Источник: European Respiratory Journal, Supplement

Выпуск: Т. 58, № S65

Держатель оригинала документа: Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science

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Association of the plasma levels and gene polymorphism IL12B, IL13 with severe asthma in Siberian children : научное издание
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