Библиографическое описание:Innovative hydrogel containing polymeric nanocapsules loaded with phloretin: Enhanced skin penetration and adhesion : научное издание / T. P.A. Casarini [et al.]. - Текст : непосредственный // Materials Science and Engineering: C. - 2021. - Т. 120, № . - P. 111681. - ISSN 0928-4931. - ISSN 1873-0191, DOI 10.1016/j.msec.2020.111681.
Аннотация:Dermatological applications of phloretin are restricted by its poor aqueous solubility. Nanotechnology has been proposed as strategy to increase the apparent drug solubility in aqueous media. This study aimed to develop, characterize, and evaluate the antitumoral effects and safety of polymeric nanocapsules containing phloretin (NCPhl). Further, to incorporate NC-Phl in an innovative semi-solid formulation (HG-NCPhl) to evaluate its performance using porcine skin model. NC-Phl was prepared and the effects in MRC5, HACAT, and SK-mel28 cells were evaluated. Hydrogels were prepared with Lecigel ® and characterized for their nanotechnological properties, adhesion (in vitro washability), and penetration/permeation studies in porcine skin. NC-Phl had a cytotoxic effect against Sk-Mel-28 cells and the population doubling time was increased upon treatment with NC-Phl for longer culture periods; notably when cells were treated for 72 h and then followed for 7 days after the treatment was removed (p < 0.05). HG-NC-Phl was considered adhesive and had a higher capacity to penetrate all skin layers compared with HG-Phl (p < 0.05). The innovative hydrogel HGNC-Phl promoted a drug-reservoir in the stratum corneum and higher penetration of the flavonoid into the epidermis. Therefore, this approach can be considered as a platform to establish versatile dermatological solutions for both cosmeceutics and melanoma therapy.
Издательство:Elsevier Science Publishing Company, Inc.
Источник:Materials Science and Engineering: C
Выпуск:Т. 120
Номера страниц:111681
Держатель оригинала документа:Faculdade de Farmácia,Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós-Graduação em Ciências Farmacêuticas,Universidade Federal do Rio Grande do Sul (UFRGS)
Количество экземпляров:
Твёрдая копия издания отсутствует в фонде библиотеки
