Библиографическое описание:Gene polymorphism IL13 in moderate-to-severe asthmatic Siberian children with different diseases control : доклад, тезисы доклада / M. Smolnikova, S. Tereshchenko, N. Gorbacheva, M. Malinchik ; BGRS/SB-2020. The 12th International Multiconference (2020 ; 06.07 - 10.07 ; Novosibirsk). - [S. l. : s. n.], 2020. - Текст : непосредственный // BIOINFORMATICS OF GENOME REGULATION AND STRUCTURE/SYSTEMS BIOLOGY (BGRS/SB-2020) : The Twelfth International Multiconference Abstracts : Institute of Cytology and Genetics, SB RAS, 2020. - P. 528-529. - ISBN 9785912910517, DOI 10.18699/BGRS/SB-2020-321.
Аннотация:Multifunctional cytokines, such as IL-13, play an important role in asthma pathogenesis. Several single nucleotide polymorphisms of cytokines are associated with asthma susceptibility in specific populations; however, further replicative studies in other ethnic groups are mandatory, especially with respect to asthma severity in children. Child with moderate-to-severe asthma were divided to patients uncontrolled course of the disease (n = 107) and controlled course of the disease (n = 95). The frequency of the CT genotype IL13 (rs1800925) in patients with controlled moderate-to-severe asthma was significantly higher in comparison with control (46,2% / 36,6%, OR 1,51, p=0,03). Was obtained statistically significant differences in the frequency of the TT genotype between the population sample (6,7%) and the group with uncontrolled asthma (15,5%, OR 1,65, p=0,03). The results have contributed to the data on the role of polymorphisms of IL-13 into the development of asthma in children as exemplified by a European population of East Siberia, Russia.
