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Segregation ofDifferentGABAAReceptors toSynaptic andExtrasynapticMembranes ofCerebellar GranuleCells Zoltán NusserWerner SieghartPéter Somogyi1998 год

Segregation of Different GABAAReceptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells
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Аннотация: Two types of GABA A receptor-mediated inhibition (phasic and tonic) have been described in cerebellar granule cells, although these cells receive GABAergic input only from a single cell type, the Golgi cell. In adult rats, granule cells express six GABA A receptor subunits abundantly (α1, α6, β2, β3, γ2, and δ), which are coassembled into at least four to six distinct GABA A receptor subtypes. We tested whether a differential distribution of GABA A receptors on the surface of granule cells could play a role in the different forms of inhibition, assuming that phasic inhibition originates from the activation of synaptic receptors, whereas tonic inhibition is provided mainly by extrasynaptic receptors. The α1, α6, β2/3, and γ2 subunits have been found by immunogold localizations to be concentrated in GABAergic Golgi synapses and also are present in the extrasynaptic membrane at a lower concentration. In contrast, immunoparticles for the δ subunit could not be detected in synaptic junctions, although they were abundantly present in the extrasynaptic dendritic and somatic membranes. Gold particles for the α6, γ2, and β2/3, but not the α1 and δ, subunits also were concentrated in some glutamatergic mossy fiber synapses, where their colocalization with AMPA-type glutamate receptors was demonstrated. The exclusive extrasynaptic presence of the δ subunit-containing receptors, together with their kinetic properties, suggests that tonic inhibition could be mediated mainly by extrasynaptic α 6 β 2/3 δ receptors, whereas phasic inhibition is attributable to the activation of synaptic α 1 β 2/3 γ 2 , α 6 β 2/3 γ 2 , and α 1 α 6 β 2/3 γ 2 receptors.
Год издания: 1998
Авторы: Zoltán Nusser, Werner Sieghart, Péter Somogyi
Издательство: Society for Neuroscience
Источник: Journal of Neuroscience
Ключевые слова: Neuroscience and Neuropharmacology Research, Neural dynamics and brain function, Lipid Membrane Structure and Behavior
Другие ссылки: Journal of Neuroscience (PDF)
Journal of Neuroscience (HTML)
Europe PMC (PubMed Central) (PDF)
Europe PMC (PubMed Central) (HTML)
PubMed Central (HTML)
PubMed (HTML)