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Electrospunantibacterialnanofibers:Production, activity,andinvivoapplications Yuan GaoYen Bach TruongYonggang Zhu2014 год

Electrospun antibacterial nanofibers: Production, activity, andin vivoapplications
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Аннотация: ABSTRACT Electrospinning is an economical and relatively simple method to produce continuous and uniform nanofibers from almost any synthetic and many natural polymers. Because of the high specific surface area, tunable pore size, and flexibility, the nanofibrous membranes are finding an increasingly wide range of applications. Some particular attention has been devoted to antibacterial nanofibers for applications such as wound dressings. A variety of biocides, e.g ., antibiotics, quaternary ammonium salts, triclosan, biguanides, (silver, titanium dioxide, and zinc oxide) nanoparticles and chitosan have been incorporated by various techniques into nanofibers that exhibit strong antibacterial activity in standard assays. However, the small diameters of the nanofibers also mean that the incorporated biocides are often burst released once the materials are submerged in an aqueous solution. Nevertheless, several strategies, such as core‐sheath structure of the nanofiber, covalent bonding of the biocide on the fiber surface and adsorption of the biocide in nanostructures, can be utilized to sustain the release over several days. This review summarizes recent development in the fabrication of antibacterial nanofibers, the release profiles of the biocides and their applications in in vivo systems. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40797.
Год издания: 2014
Авторы: Yuan Gao, Yen Bach Truong, Yonggang Zhu, Ilias Louis Kyratzis
Издательство: Wiley
Источник: Journal of Applied Polymer Science
Ключевые слова: Electrospun Nanofibers in Biomedical Applications, Antimicrobial agents and applications, Advanced Sensor and Energy Harvesting Materials