Type I photosensitizers based on phosphindole oxide for photodynamic therapy: apoptosis and autophagy induced by endoplasmic reticulum stress

Z Zhuang, J Dai, M Yu, J Li, P Shen, R Hu, X Lou… - Chemical …, 2020 - pubs.rsc.org
Photodynamic therapy (PDT) is considered a pioneering and effective modality for cancer
treatment, but it is still facing challenges of hypoxic tumors. Recently, Type I PDT, as an …

AIEgens based on main group heterocycles

P Shen, Z Zhuang, Z Zhao, BZ Tang - Journal of Materials Chemistry C, 2018 - pubs.rsc.org
Aggregation-induced emission (AIE) is an intriguing and significant photophysical phenomenon
currently attracting intense research interest. Different from conventional luminophores …

Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Z Zhuang, J Li, P Shen, Z Zhao, BZ Tang - Aggregate, 2024 - Wiley Online Library
Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven
substantial advances in multifunction phototheranostic platforms. As exemplified by two typical …

Steric, conjugation and electronic impacts on the photoluminescence and electroluminescence properties of luminogens based on phosphindole oxide

Z Zhuang, F Bu, W Luo, H Peng, S Chen… - Journal of Materials …, 2017 - pubs.rsc.org
Aggregation-induced emission (AIE) is currently receiving intense interest because of its
important implications in photophysics. The structure-property relationship decipherment of AIE …

Antibacterial theranostic agents with negligible living cell invasiveness: AIE-active cationic amphiphiles regulated by alkyl chain engineering

Z Zhuang, Z Meng, J Li, P Shen, J Dai, X Lou, F Xia… - ACS …, 2022 - ACS Publications
To address the threat of bacterial infection in the following post-antibiotic era, developing
effective antibacterial approaches is of utmost urgency. Theranostic medicine integrating …

Type I AIE photosensitizers: Mechanism and application

J Li, Z Zhuang, Z Zhao, BZ Tang - View, 2022 - Wiley Online Library
Photodynamic therapy (PDT) with plenty of advantages is expected to become a promising
modality for cancer treatment, but challenges still remain. In the past decade, abundant …

Molecular engineering to boost AIE‐active free radical photogenerators and enable high‐performance photodynamic therapy under hypoxia

Q Wan, R Zhang, Z Zhuang, Y Li… - Advanced Functional …, 2020 - Wiley Online Library
The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence
quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of …

Highly efficient nondoped OLEDs with negligible efficiency roll‐off fabricated from aggregation‐induced delayed fluorescence luminogens

J Huang, H Nie, J Zeng, Z Zhuang… - Angewandte Chemie …, 2017 - Wiley Online Library
Purely organic emitters that can efficiently utilize triplet excitons are highly desired to cut the
cost of organic light‐emitting diodes (OLEDs), but most of them require complicated doping …

Cationization-enhanced type I and type II ROS generation for photodynamic treatment of drug-resistant bacteria

S Liu, B Wang, Y Yu, Y Liu, Z Zhuang, Z Zhao, G Feng… - ACS …, 2022 - ACS Publications
Photodynamic therapy as an emerging phototheranostic approach holds great potential for
antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) …

Self-adaptive photodynamic-to-photothermal switch for smart antitumor photoimmunotherapy

Y Yu, H Wang, Z Zhuang, C Ji, L Zhang, Y Li, Z Zhao… - ACS …, 2024 - ACS Publications
Photodynamic therapy (PDT) and photothermal therapy (PTT) possess different merits in
cancer phototherapy, but the tumor microenvironment becomes unfavorable during the …