Microplastics (MPs) are a ubiquitous pollutant detected not only in marine and freshwater
bodies, but also in tap and bottled water worldwide. While MPs have been extensively studied, …

The Ubiquitin-Proteasome Pathway (UPP), which is critical for normal function in the nervous
system and is implicated in various neurological diseases, requires the small modifier …

Polyglutamine repeat expansion in ataxin-3 causes neurodegeneration in the most common
dominant ataxia, spinocerebellar ataxia type 3 (SCA3). Since reducing levels of disease …

Deubiquitinating enzymes (DUBs) are proteases that control the post-translational modification
of proteins by ubiquitin and in turn regulate diverse cellular pathways. Despite a growing …

Deubiquitinases (DUBs) are proteases that regulate various cellular processes by controlling
protein ubiquitination. Cell-based studies indicate that the regulation of the activity of DUBs …

Ataxin-3 is a deubiquitinase and polyglutamine (polyQ) disease protein with a protective role
in Drosophila melanogaster models of neurodegeneration. In the fruit fly, wild-type ataxin-3 …

Spinocerebellar ataxia type 6 (SCA6) belongs to the family of CAG/polyglutamine (polyQ)-dependent
neurodegenerative disorders. SCA6 is caused by abnormal expansion in a CAG …

Age‐related neurodegeneration has been studied extensively through the use of model
organisms, including the genetically versatile Drosophila melanogaster. Various neurotoxic …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

Polyglutamine (polyQ) repeat expansion in the deubiquitinase ataxin-3 causes neurodegeneration
in Spinocerebellar Ataxia Type 3 (SCA3), one of nine inherited, incurable diseases …