… A complex scenario is evident, where the production of some cytokines increases with age
while that of others decreases (based on data reported in Fagiolo et al.. 1993, and manuscript …

The production of cytokines during aging, except interleukin (IL)‐2, has been neglected in
humans. We measured the in vitro production of IL‐6, tumor necrosis factor (TNF)‐α, interferon …

To investigate the prevalence of thyroid autoantibodies in very old subjects, we assayed
sera from 34 healthy centenarians (7 men, 27 women; age range 100-108 years) for these …

… mL; values above 120 U/mL for anti-Tg and above 10 U/mL for anti-TPO … groups were then
evaluated by Mann-Whitney U test. … Paganelli R, Quinti I, Fagiolo U, et al. 1992 Changes in …

CD4 + and CD8 + peripheral blood T lymphocytes show mutually exclusive expression of
CD45RA or CD45R0, two isoforms of the common leukocyte antigen that seem to recognize so…

The study of 87 adults of different ages, including 15 centenarians, selected for their healthy
status, showed that profound changes of humoral immunity occur throughout life. In …

… and RIA techniques, antibody levels were expressed in international units (U/ml); values
>120 U/rnl were conн sidered positive anti-TG and >10 U/ml positive antiTPO assays. …

… The cells were stimulated with the following growth factors: 2 U/mL human recombinant (hr)
erythropoietin (hrEpo) (Cilag Chemi), 2 ng/mL hr interleukin3 (IL-3), and 50 ng/mL hr GM-…

Human plasma or serum from donors of age comprised between 15 and 95 years was analyzed
for paramagnetic and total copper content, as well as for immunoreactive ceruloplasmin …

Background: Intradermal injection of autologous serum elicits a wheal-and-flare response in
about 60% of patients with chronic idiopathic urticaria (CIU). This reactivity has been …