User profiles for Tânia Francisco
 | Tânia FranciscoInvestigadora Júnior, i3S, Universidade do Porto Verified email at ibmc.up.pt Cited by 1288 |
[HTML][HTML] Methylation defects of imprinted genes in human testicular spermatozoa
CJ Marques, T Francisco, S Sousa, F Carvalho… - Fertility and sterility, 2010 - Elsevier
OBJECTIVE: To study the methylation imprinting marks of two oppositely imprinted genes,
H19 and MEST/PEG1, in human testicular spermatozoa from azoospermic patients with …
H19 and MEST/PEG1, in human testicular spermatozoa from azoospermic patients with …
Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate
CP Grou, T Francisco, TA Rodrigues, MO Freitas… - Journal of Biological …, 2012 - jbc.org
Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized
peroxisomal matrix proteins in the cytosol and promotes their translocation across the organelle …
peroxisomal matrix proteins in the cytosol and promotes their translocation across the organelle …
[HTML][HTML] PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14
MO Freitas, T Francisco, TA Rodrigues… - Journal of biological …, 2011 - Elsevier
Newly synthesized peroxisomal matrix proteins are targeted to the organelle by PEX5. PEX5
has a dual role in this process. First, it acts as a soluble receptor recognizing these proteins …
has a dual role in this process. First, it acts as a soluble receptor recognizing these proteins …
Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts
M Nordgren, T Francisco, C Lismont, L Hennebel… - Autophagy, 2015 - Taylor & Francis
Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a healthy
cellular environment, dysfunctional and superfluous peroxisomes need to be selectively …
cellular environment, dysfunctional and superfluous peroxisomes need to be selectively …
Protein transport into peroxisomes: Knowns and unknowns
T Francisco, TA Rodrigues, AF Dias… - …, 2017 - Wiley Online Library
Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported
into the organelle by a complex machinery. The data gathered in recent years suggest that …
into the organelle by a complex machinery. The data gathered in recent years suggest that …
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol
PEX1 and PEX6 are two members of the ATPases associated with diverse cellular activities
(AAA) family and the core components of the receptor export module of the peroxisomal …
(AAA) family and the core components of the receptor export module of the peroxisomal …
[HTML][HTML] The mammalian peroxisomal membrane is permeable to both GSH and GSSG–Implications for intraperoxisomal redox homeostasis
Despite the large amounts of H 2 O 2 generated in mammalian peroxisomes, cysteine residues
of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind …
of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind …
A cargo-centered perspective on the PEX5 receptor-mediated peroxisomal protein import pathway
T Francisco, TA Rodrigues, MO Freitas, CP Grou… - Journal of Biological …, 2013 - jbc.org
Background: How the soluble receptor PEX5 delivers its cargoes to the peroxisome remains
largely unknown. Results: Cargo translocation occurs after docking of the receptor at the …
largely unknown. Results: Cargo translocation occurs after docking of the receptor at the …
Membrane topologies of PEX 13 and PEX 14 provide new insights on the mechanism of protein import into peroxisomes
…, CP Grou, MP Pinto, M Fransen, T Francisco… - The FEBS …, 2019 - Wiley Online Library
PEX 13 and PEX 14 are two core components of the so‐called peroxisomal docking/translocation
module, the transmembrane hydrophilic channel through which newly synthesized …
module, the transmembrane hydrophilic channel through which newly synthesized …
An efficient protocol for the detection of chromosomal abnormalities in spontaneous miscarriages or foetal deaths
…, F Carvalho, C Ramalho, V Lima, T Francisco… - European Journal of …, 2009 - Elsevier
OBJECTIVE: Characterization of chromosomal abnormalities in 232 spontaneous miscarriages
or foetal deaths using both classical and molecular cytogenetics. STUDY DESIGN: …
or foetal deaths using both classical and molecular cytogenetics. STUDY DESIGN: …
