Significance: Iron accumulation occurs in the central nervous system (CNS) in a variety of
neurological conditions as diverse as spinal cord injury, stroke, multiple sclerosis, Parkinson's …

Ceruloplasmin (Cp) is a ferroxidase that converts highly toxic ferrous iron to its non-toxic ferric
form. A glycosylphosphatidylinositol (GPI)-anchored form of this enzyme is expressed by …

Ceruloplasmin is a ferroxidase that oxidizes toxic ferrous iron to its nontoxic ferric form. We
have previously reported that a glycosylphosphatidylinositol-anchored form of ceruloplasmin …

Ferroportin (Fpn), a ferrous iron Fe(II) transporter responsible for the entry of iron into plasma,
is regulated post‐translationally through internalization and degradation following binding …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized
by cortical and spinal motor neuron dysfunction. Routine magnetic resonance imaging (…

Glutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a
zebrafish model and of sideroblastic anemia in a human patient. Here we report that GLRX5 …

Inactivation of the TCA cycle enzyme, fumarate hydratase (FH), drives a metabolic shift to
aerobic glycolysis in FH-deficient kidney tumors and cell lines from patients with hereditary …

Iron is essential for a variety of cellular functions, but its levels and bioavailability must be
tightly regulated because of its toxic redox activity. A number of transporters, binding proteins, …

Amyotrophic lateral sclerosis (ALS), characterized by degeneration of spinal motor neurons,
consists of sporadic and familial forms. One cause of familial ALS is missense mutations in …

Studies aimed at supporting different treatment approaches for pantothenate kinase-associated
neurodegeneration (PKAN) have revealed the complexity of coenzyme A (CoA) …