Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML-and PLZF-RARα underlie molecular pathogenesis and treatment of acute …
F Guidez, S Ivins, J Zhu… - Blood, The Journal …, 1998 - ashpublications.org
Typical acute promyelocytic leukemia (APL) is associated with expression of the PML-RARα
fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, …
fusion protein and responsiveness to treatment with all-trans retinoic acid (ATRA). A rare, …
The CXCL12/CXCR4 axis plays a critical role in coronary artery development
S Ivins, J Chappell, B Vernay, J Suntharalingham… - Developmental cell, 2015 - cell.com
The chemokine CXCL12 and its receptor CXCR4 have many functions during embryonic and
post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling …
post-natal life. We used murine models to investigate the role of CXCL12/CXCR4 signaling …
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm
A Calmont, S Ivins, KL Van Bueren… - …, 2009 - journals.biologists.com
Elucidating the gene regulatory networks that govern pharyngeal arch artery(PAA) development
is an important goal, as such knowledge can help to identify new genes involved in …
is an important goal, as such knowledge can help to identify new genes involved in …
The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis
R Shaknovich, PL Yeyati, S Ivins… - … and cellular biology, 1998 - Taylor & Francis
The promyelocytic leukemia zinc finger (PLZF) gene, which is disrupted in therapy-resistant,
t(11;17)(q23;q21)-associated acute promyelocytic leukemia (APL), is expressed in immature …
t(11;17)(q23;q21)-associated acute promyelocytic leukemia (APL), is expressed in immature …
Retinoic acid down‐regulates Tbx1 expression in vivo and in vitro
C Roberts, SM Ivins, CT James… - … dynamics: an official …, 2005 - Wiley Online Library
Both Tbx1 and retinoic acid (RA) are key players in embryonic pharyngeal development;
loss of Tbx1 produces DiGeorge syndrome‐like phenotypes in mouse models as does …
loss of Tbx1 produces DiGeorge syndrome‐like phenotypes in mouse models as does …
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the …
Cyp26a1, a gene required for retinoic acid (RA) inactivation during embryogenesis, was
previously identified as a potential Tbx1 target from a microarray screen comparing wild-type …
previously identified as a potential Tbx1 target from a microarray screen comparing wild-type …
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein
Histone acetyltransferase (HAT) activities of proteins such as p300, CBP, and P/CAF play
important roles in activation of gene expression. We now show that the HAT activity of p300 …
important roles in activation of gene expression. We now show that the HAT activity of p300 …
Two critical hits for promyelocytic leukemia
LZ He, M Bhaumik, C Tribioli, EM Rego, S Ivins… - Molecular cell, 2000 - cell.com
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations that
always involve the RARα gene, which variably fuses to one of several distinct loci, including …
always involve the RARα gene, which variably fuses to one of several distinct loci, including …
[HTML][HTML] Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1
S Ivins, KL van Beuren, C Roberts, C James… - Developmental …, 2005 - Elsevier
22q11-deletion (DiGeorge/velocardiofacial) syndrome (22q11DS) is modeled by mutation
of murine transcription factor Tbx1. As part of efforts to identify transcriptional targets of Tbx1, …
of murine transcription factor Tbx1. As part of efforts to identify transcriptional targets of Tbx1, …
XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis
P Ataliotis, S Ivins, TJ Mohun… - … Dynamics: An Official …, 2005 - Wiley Online Library
The development of pharyngeal arch derivatives in mouse and zebrafish embryos depends
on the activity of the transcription factor Tbx1. We cloned the Xenopus laevis orthologue of …
on the activity of the transcription factor Tbx1. We cloned the Xenopus laevis orthologue of …