A series of C-glucosides with various heteroaromatics has been synthesized and its
inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the …

The total synthesis of a new platelet aggregation-inhibiting γ-lactam PI-091 (1) gave a 1:1
diastereomeric mixture at the γ-ketal carbon. The high-yielding aldol reaction of an …

C (aryl)–C (═ O) bonds of aryl amides can be activated and added across alkenes with the
aid of a nickel catalyst. This 1, 2-carboaminocarbonylation reaction enables the …

Total synthesis of PI-091 (1), a novel platelet aggregation inhibitor, has been accomplished.
The known D-glucose-derived branched sugar 2 was converted efficiently to a 2,4-…

We describe the total syntheses of natural pseurotins A and F 2 , inhibitors of chitin synthase,
both of which possess an unusual 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione ring system. …

Background Dialysis patients often have low physical performance due to uremic sarcopenia,
protein energy wasting (PEW), and incidence intradialytic hypotension (IDH), which are …

We report a directing group (DG)-enabled strategy for polyamide depolymerization. Pyridine-based
DGs selectively interact with In(III) catalysts, activating amide bonds for catalytic …

A series of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives were prepared and evaluated
as inhibitors of human liver glycogen phosphorylase a (hLGPa). One compound, 5-chloro…

As a result of the various N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives with a
hydroxy moiety synthesized in an effort to discover novel glycogen phosphorylase (GP) …

We have achieved the total synthesis of (−)-verrucarol, a trichothecene sesquiterpenoid
obtained as a hydrolysis product of the naturally occurring verrucarin A. Our total synthesis …